Ovarian tissue cryopreservation: low usage rates and high live-birth rate after transplantation
| Autor: | Ellen J. Hoekman, Cornelis D. de Kroon, Maxime Rooijers, Carina G. J. M. Hilders, Gonneke S. K. Pilgram, Nicole F. Klijn, Lucette A. J. van der Westerlaken, Leoni A. Louwe |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty premature ovarian insufficiency Adolescent endocrine system diseases fertility preservation medicine.medical_treatment media_common.quotation_subject Antineoplastic Agents Fertility Primary Ovarian Insufficiency Premature ovarian insufficiency cryopreservation Transplantation Autologous Cryopreservation 03 medical and health sciences 0302 clinical medicine medicine ovarian tissue transplantation Humans Ovarian tissue cryopreservation Original Research Article 030212 general & internal medicine Fertility preservation Birth Rate Child ovarian tissue Netherlands media_common 030219 obstetrics & reproductive medicine Obstetrics business.industry Ovary Obstetrics and Gynecology General Medicine Autotransplantation Transplantation Quality of Life Female Live birth business |
| Zdroj: | Acta Obstetricia et Gynecologica Scandinavica, 99(2), 213-221. WILEY Acta Obstetricia et Gynecologica Scandinavica |
| Popis: | Introduction The likelihood of survival after cancer treatment among young women with cancer has increased considerably, quality of life after treatment has drawn more attention. However, in young fertile women, fertility preservation is an important issue with regard to quality of life. One of the options of fertility preservation is ovarian tissue cryopreservation. The purpose of this follow‐up study is to present our clinical experiences and evaluate the long‐term follow up of ovarian cryopreservation to improve future patient selection. Material and methods From July 2002 to December 2015 at the Leiden University Hospital, the Netherlands, 69 young women underwent ovarian tissue cryopreservation when they were at risk of iatrogenic premature ovarian insufficiency. Follow‐up data with regard to ovarian function were obtained until October 2018, from medical records and questionnaires. Results Of the 69 women in whom ovarian tissue cryopreservation was performed, 12 died (15.9%), 57 were approached to participate, of which 6 were lost to follow up. The indications for ovarian tissue cryopreservation were malignant (81.1%) and benign (18.9%) diseases in which gonadotoxic treatment was scheduled. In total, twenty women (39.2%) are known to have premature ovarian insufficiency due to gonadotoxic treatment. Fifteen women conceived spontaneously, and delivered 25 babies. In this cohort, the usage rate of autotransplantation is 8.7% (7/69). In total, nine autotransplantations of cryopreserved ovarian tissue were performed in seven patients (of which 1 ovarian tissue cryopreservation was performed in another hospital) after which 6 babies were born to four women, giving a live‐birth rate of 57%. Conclusions Ovarian tissue cryopreservation followed by autotransplantation is an effective method to restore fertility (live‐birth rate of 57%). The usage rate of 8.7% (6/69) indicates that more knowledge about the risk of premature ovarian insufficiency after gonadotoxic treatment is needed to be able to offer ovarian tissue cryopreservation more selectively. |
| Databáze: | OpenAIRE |
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