Altered spontaneous brain activity in Cushing's disease: a resting-state functional MRI study
| Autor: | Yuhao Sun, Fuhua Yan, Naying He, Hong Jiang, Liuguan Bian, Si-Jian Pan, Qingfang Sun, Jian-kang Shen, Fangfang Jian |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Brain activity and meditation Endocrinology Diabetes and Metabolism Thalamus Precuneus 030209 endocrinology & metabolism Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Humans Pituitary ACTH Hypersecretion Cushing Syndrome Resting state fMRI business.industry Brain Human brain Cushing's disease Middle Aged medicine.disease Magnetic Resonance Imaging Cross-Sectional Studies medicine.anatomical_structure Case-Control Studies Posterior cingulate Occipital lobe business 030217 neurology & neurosurgery |
| Zdroj: | Clinical Endocrinology. 86:367-376 |
| ISSN: | 0300-0664 |
| DOI: | 10.1111/cen.13277 |
| Popis: | SummaryContext and objective Cushing's disease (CD) provides a unique and naturalist model for studying the influence of hypercortisolism on the human brain and the reversibility of these effects after resolution of the condition. This cross-sectional study used resting-state fMRI (rs-fMRI) to investigate the altered spontaneous brain activity in CD patients and the trends for potential reversibility after the resolution of the hypercortisolism. We also aim to determine the relationship of these changes with clinical characteristics and cortisol levels. Subjects and methods Active CD patients (n = 18), remitted CD patients (n = 14) and healthy control subjects (n = 22) were included in this study. Amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) values were calculated to represent spontaneous brain activity. Results Our study resulted in three major findings: (i) active CD patients showed significantly altered spontaneous brain activity in the posterior cingulate cortex (PCC)/precuneus (PCu), occipital lobe (OC)/cerebellum, thalamus, right postcentral gyrus (PoCG) and left prefrontal cortex (PFC); (ii) trends for partial restoration of altered spontaneous brain activity after the resolution hypercortisolism were found in several brain regions; and (iii) active CD patients showed a significant correlation between cortisol levels and ALFF/ReHo values in the PCC/PCu, a small cluster in the OC and the right IPL. Conclusions This study provides a new approach to investigating brain function abnormalities in patients with CD and enhances our understanding of the effect of hypercortisolism on the human brain. Furthermore, our explorative potential reversibility study of patients with CD may facilitate the development of future longitudinal studies. |
| Databáze: | OpenAIRE |
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