Effect of two hypercaloric diets on the hormonal and metabolic profile of the adrenal gland
| Autor: | Mokrani Zoulikha, Gernigon-Spichalowicz Therese, Zerrouki Nacira, Soltani Yacine |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Adipose tissue 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Internal medicine Adrenal Glands medicine Animals Metabolomics Molecular Biology business.industry Adrenal gland Insulin Leptin General Medicine medicine.disease Hormones Diet Steroid hormone 030104 developmental biology medicine.anatomical_structure Adipose Tissue Metabolome Rabbits business Energy Metabolism Dyslipidemia Hormone |
| Zdroj: | Hormone molecular biology and clinical investigationReferences. 42(4) |
| ISSN: | 1868-1891 |
| Popis: | Objectives Who disrupts who? It is not clear what the interaction is between a high calorie diet (HCD) and adrenal axis activation in obesity. The goal was to assess the effect of two hypercaloric diets commercialized in Algeria on the hormonal and metabolic profile of the adrenal gland in rabbits. Methods Two classes of local male adult rabbits (n=16) and a finishing diet (FD) as a control for 15 weeks. Results It has been shown that HCD-received animals have developed visceral obesity, dyslipidemia and insulin resistance IR by dramatically increasing body weight, visceral fat tissue and adrenal weight, combined with elevated plasma levels of ACTH, cortisol, leptin and insulin. The HCD diet increased the levels of cortisol in the visceral adipose tissue (VAT), in peri-adrenal adipose tissue (PAAT), and decreased cortisol levels in the liver. HCD also causes the process of inflammatory fibrosis associated with the migration and spread of chromaffin cells in the adrenal gland. Conclusions This study gives new insights into how diet-induced obesity studied on local rabbits affects the biology of the adrenal gland. The correlation of these changes with paracrine connections between the chromaffin cell and glomerulosa indicates potential therapeutic methods for obese-related steroid hormone dysfunction. |
| Databáze: | OpenAIRE |
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