The impact of an URAT1 polymorphism on the losartan treatment of hypertension and hyperuricemia
| Autor: | Liting Wu, Yingchao Fan, Zhumeng Li, Wenfang Zhuang, Delong Mao, Yuan Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
CYP2C9
Adult Male Microbiology (medical) medicine.medical_specialty Uricosuric Organic Cation Transport Proteins Pharmacogenomic Variants losartan Clinical Biochemistry Organic Anion Transporters Single-nucleotide polymorphism Hyperuricemia Creatine Polymorphism Single Nucleotide chemistry.chemical_compound Polymorphism (computer science) Internal medicine Humans Immunology and Allergy Medicine hypertension with hyperuricemia Research Articles Antihypertensive Agents Aged Cytochrome P-450 CYP2C9 business.industry Biochemistry (medical) Public Health Environmental and Occupational Health Hematology Middle Aged medicine.disease Pharmacogenomic Testing Medical Laboratory Technology Endocrinology Losartan chemistry Hypertension Female URAT1 business Research Article Lipoprotein medicine.drug |
| Zdroj: | Journal of Clinical Laboratory Analysis |
| ISSN: | 1098-2825 0887-8013 |
| DOI: | 10.1002/jcla.23949 |
| Popis: | Background This study was designed to evaluate the impact of polymorphisms in the urate transporter 1 (URAT1) gene on the uricosuric action of losartan therapy in hypertensive patients suffering from hyperuricemia. Methods A MassARRAY approach was used to detect single nucleotide polymorphism (SNP) loci in the URAT1 and CYP2C9 genes (16 and 2 loci, respectively) in 111 patients with hypertension and hyperuricemia taking losartan and in 121 healthy controls. In addition, we compared serum urate (SUA) levels and other key clinical biochemistry indices between these two patient groups. Results We detected significant differences between the two patient groups with respect to age, SUA, urea, creatine, triglycerides, high‐density lipoprotein, low‐density lipoprotein, and fasting plasma glucose (all p 121 healthy people and 111 patients with hypertension and hyperuric acid were screened out, 16 SNP loci of URAT.1 and 2 SNP loci of CYP2C9 were detected by MASS‐ARRAY technology. Through analysis, it was found that only rs3825016 was meaningful, We observed that patients with the heterozygous genotype (CT) exhibited a more pronounced decrease in uric acid levels. |
| Databáze: | OpenAIRE |
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