Topical drug delivery: History, percutaneous absorption, and product development

Autor: Yousuf H. Mohammed, Azadeh Alinaghi, Amy Holmes, John van der Hoek, Hanumanth Srikanth Cheruvu, Heather A. E. Benson, Michael Pastore, Sean E. Mangion, Michael S. Roberts, Jeffrey E. Grice
Přispěvatelé: Roberts, Michael S, Cheruvu, Hanumanth S, Mangion, Sean E, Alinaghi, Azadeh, Benson, Heather AE, Mohammed, Yousuf, Holmes, Amy, van der Hoek, John, Pastore, Michael, Grice, Jeffrey E
Rok vydání: 2021
Předmět:
PBPK
Physiologically based pharmacokinetic modelling
Administration
Topical
Skin Absorption
topical drug delivery
Population
mechanism
Pharmaceutical Science
clearance
consumer behavior
Computational biology
Models
Biological
030226 pharmacology & pharmacy
IVPT
030207 dermatology & venereal diseases
03 medical and health sciences
Drug Delivery Systems
0302 clinical medicine
Drug Development
finite dose
Pharmacokinetics
QSPR
Animals
Humans
product development
education
History
Ancient
History
15th Century
Skin
Drug transport
bioequivalence
education.field_of_study
Topical drug
integumentary system
Product design
business.industry
Chemistry
skin and its appendages
History
19th Century
History
20th Century
History
Medieval
3. Good health
percutaneous absorption
History
16th Century
Percutaneous absorption
New product development
history
heterogeneity
business
Zdroj: Advanced Drug Delivery Reviews. 177:113929
ISSN: 0169-409X
DOI: 10.1016/j.addr.2021.113929
Popis: Refereed/Peer-reviewed Topical products, widely used to manage skin conditions, have evolved from simple potions to sophisticated delivery systems. Their development has been facilitated by advances in percutaneous absorption and product design based on an increasingly mechanistic understanding of drug-product-skin interactions, associated experiments, and a quality-by-design framework. Topical drug delivery involves drug transport from a product on the skin to a local target site and then clearance by diffusion, metabolism, and the dermal circulation to the rest of the body and deeper tissues. Insights have been provided by Quantitative Structure Permeability Relationships (QSPR), molecular dynamics simulations, and dermal Physiologically Based PharmacoKinetics (PBPK). Currently, generic product equivalents of reference-listed products dominate the topical delivery market. There is an increasing regulatory interest in understanding topical product delivery behavior under ‘in use’ conditions and predicting in vivo response for population variations in skin barrier function and response using in silico and in vitro findings.
Databáze: OpenAIRE
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