An initial dosing method for teicoplanin based on the area under the serum concentration time curve required for MRSA eradication
| Autor: | Akari Shigemi, Keiko Yaji, Norifumi Morikawa, Naoko Kanazawa, Tomohide Fukamizu, Katsushi Yamada, Kazuaki Matsumoto, Kazuro Ikawa, Yasuo Takeda, Yoshihiro Shimodozono |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Methicillin-Resistant Staphylococcus aureus Microbiology (medical) medicine.medical_specialty Population Urology Renal function Pharmacology Loading dose Pharmacokinetics medicine Humans Pharmacology (medical) Trough Concentration education Antibacterial agent education.field_of_study medicine.diagnostic_test Teicoplanin business.industry Staphylococcal Infections Anti-Bacterial Agents Nomograms Infectious Diseases Therapeutic drug monitoring Area Under Curve Drug Monitoring business Software medicine.drug |
| Zdroj: | Journal of Infection and Chemotherapy. 17:297-300 |
| ISSN: | 1341-321X |
| Popis: | Teicoplanin is a glycopeptide antibacterial agent that has a long serum half-life and therefore takes time to achieve steady-state conditions. An appropriate initial dosing is needed for teicoplanin to promptly reach an effective serum trough concentration. However, little information is available on tailoring the initial dosing for patients with various characteristics. The objective of this study was to develop a nomogram for determining teicoplanin initial dose to promptly reach an effective trough concentration (≥ 13 μg/mL). A logistic regression analysis was performed to test whether the area under the concentration time curve (AUC) is a significant predictor of microbiological response (persistence 0; eradication 1). The study included 24 adult patients with methicillin-resistant Staphylococcus aureus infections [minimal inhibitory concentration (MIC) for the isolates was |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect