Liver metastases from colorectal cancer: regional intra-arterial treatment following failure of systemic chemotherapy
| Autor: | Erica Rakowsky, Eli Atar, A Belinky, R Hardoff, M Neuman-Levin, F Greif, A Cyjon, Baruch Brenner, Aaron Sulkes |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Neutropenia medicine.medical_treatment Leucovorin colorectal cancer Gastroenterology Liver disease Median follow-up Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine regional intra-arterial Humans Infusions Intra-Arterial Fatigue Survival analysis Aged Chemotherapy Performance status business.industry Standard treatment Liver Neoplasms Regular Article Combination chemotherapy Middle Aged medicine.disease Survival Analysis Surgery Treatment Outcome Oncology Drug Resistance Neoplasm Female Fluorouracil Cisplatin Colorectal Neoplasms business liver metastases |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1054/bjoc.2001.1972 |
| Popis: | This study was designed to determine response rate, survival and toxicity associated with combination chemotherapy delivered intra-arterially to liver in patients with hepatic metastases of colorectal origin refractory to standard systemic treatment. A total of 28 patients who failed prior systemic treatment with fluoropyrimidines received a median of 5 cycles of intra-arterial treatment consisting of 5-fluorouracil 700 mg/m2/d, leucovorin 120 mg/m2/d, and cisplatin 20 mg/m2/d for 5 consecutive days. Cycles were repeated at intervals of 5–6 weeks. A major response was achieved in 48% of patients: complete response in 8% and partial response in 40%. The median duration of response was 11.5 months. Median survival was 12 months at a median follow up of 12 months. On multivariate analysis, the only variables with a significant impact on survival were response to treatment and performance status. Toxicity was moderate: grades III–IV neutropenia occurred in 29% of patients. Most of the patients complained of fatigue lasting for a few days following each cycle. There were no cases of hepatobiliary toxicity. These findings indicate that regional intra-arterial treatment should be considered in selected patients with predominantly liver disease following failure of standard treatment. © 2001 Cancer Research Campaign http://www.bjcancer.com |
| Databáze: | OpenAIRE |
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