Perspectives and Advances in the Understanding of Tuberculosis
| Autor: | Anne E. Mayer Bridwell, Christina L. Stallings, Gregory A. Harrison, Jerome Prusa, Dennis X. Zhu, Rachel L. Kinsella, Sthefany M. Chavez |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Tuberculosis biology business.industry Tb control Host response Antitubercular Agents Disease Mycobacterium tuberculosis biology.organism_classification medicine.disease Pathology and Forensic Medicine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Pandemic Medicine Humans business Intensive care medicine 030217 neurology & neurosurgery |
| Zdroj: | Annual review of pathology. 16 |
| ISSN: | 1553-4014 |
| Popis: | Mycobacterium tuberculosis ( Mtb), the causative agent of tuberculosis (TB), remains a leading cause of death due to infection in humans. To more effectively combat this pandemic, many aspects of TB control must be developed, including better point of care diagnostics, shorter and safer drug regimens, and a protective vaccine. To address all these areas of need, better understanding of the pathogen, host responses, and clinical manifestations of the disease is required. Recently, the application of cutting-edge technologies to the study of Mtb pathogenesis has resulted in significant advances in basic biology, vaccine development, and antibiotic discovery. This leaves us in an exciting era of Mtb research in which our understanding of this deadly infection is improving at a faster rate than ever, and renews hope in our fight to end TB. In this review, we reflect on what is known regarding Mtb pathogenesis, highlighting recent breakthroughs that will provide leverage for the next leaps forward in the field. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|