Age-related differences on event-related potentials and brain rhythm oscillations during working memory activation
| Autor: | Christelle Rodriguez, Gabriel Gold, Panteleimon Giannakopoulos, François Herrmann, Lara Fazio-Costa, Pascal Missonnier, Marie-Pierre Deiber, Phiippe Millet |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Cerebral Cortex/physiology Aging Aging/physiology/psychology Posterior parietal cortex Electroencephalography Audiology Stimulus (physiology) Brain Waves/physiology Evoked Potentials/physiology Developmental psychology ddc:616.89 Young Adult Event-related potential Biological Clocks medicine Humans Effects of sleep deprivation on cognitive performance Evoked Potentials Biological Psychiatry Aged Aged 80 and over Cerebral Cortex medicine.diagnostic_test Working memory Memory Short-Term/physiology Middle Aged Brain Waves Functional imaging Psychiatry and Mental health medicine.anatomical_structure Memory Short-Term Neurology Cerebral cortex ddc:618.97 Biological Clocks/physiology Female Neurology (clinical) Psychology |
| Zdroj: | Journal of Neural Transmission, Vol. 118, No 6 (2011) pp. 945-55 |
| ISSN: | 1435-1463 0300-9564 |
| Popis: | Previous functional imaging studies have pointed to the compensatory recruitment of cortical circuits in old age in order to counterbalance the loss of neural efficiency and preserve cognitive performance. Recent electroencephalographic (EEG) analyses reported age-related deficits in the amplitude of an early positive-negative working memory (PN(wm)) component as well as changes in working memory (WM)-load related brain oscillations during the successful performance of the n-back task. To explore the age-related differences of EEG activation in the face of increasing WM demands, we assessed the PN(wm) component area, parietal alpha event-related synchronization (ERS) as well as frontal theta ERS in 32 young and 32 elderly healthy individuals who successfully performed a highly WM demanding 3-back task. PN(wm) area increased with higher memory loads (3- and 2-back > 0-back tasks) in younger subjects. Older subjects reached the maximal values for this EEG parameter during the less WM demanding 0-back task. They showed a rapid development of an alpha ERS that reached its maximal amplitude at around 800 ms after stimulus onset. In younger subjects, the late alpha ERS occurred between 1,200 and 2,000 ms and its amplitude was significantly higher compared with elders. Frontal theta ERS culmination peak decreased in a task-independent manner in older compared with younger cases. Only in younger individuals, there was a significant decrease in the phasic frontal theta ERS amplitude in the 2- and 3-back tasks compared with the detection and 0-back tasks. These observations suggest that older adults display a rapid mobilization of their neural generators within the parietal cortex to manage very low demanding WM tasks. Moreover, they are less able to activate frontal theta generators during attentional tasks compared with younger persons. |
| Databáze: | OpenAIRE |
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