Caged Pt Nanoclusters Exhibiting Corrodibility to Exert Tumor-Inside Activation for Anticancer Chemotherapeutics
| Autor: | Jia-Ying Yan, Chih-Te Chien, Wan-Ching Chiu, Te-Haw Wu, Shu-Yi Lin, Chia-Yeh Liu |
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| Rok vydání: | 2013 |
| Předmět: |
Dendrimers
Materials science Cell Survival Stereochemistry Transplantation Heterologous Cancer therapy Mice Nude Antineoplastic Agents Peptide Carboplatin Nanoclusters Mice In vivo Cell Line Tumor Neoplasms Dendrimer PEG ratio Animals Humans General Materials Science Platinum nanoclusters Platinum chemistry.chemical_classification Drug Carriers Mechanical Engineering Magnetic Resonance Imaging Nanostructures Radiography Systemic toxicity chemistry Mechanics of Materials Biophysics Cisplatin |
| Zdroj: | Advanced Materials. 25:5067-5073 |
| ISSN: | 0935-9648 |
| Popis: | We report on caged Pt nanoclusters that are able to exert tumor-inside activation for anticancer chemotherapeutics and to minimize systemic toxicity. By shrinking the Pt size to 1 nm, it possesses corrodibility for dissolution in weakly acidic organelles to release toxic Pt ions. The therapeutic effect in exerting tumor-inside activation is confirmed in vivo by post-modifying a pH-cleavable PEG corona and mixing it with a tumor-homing peptide for tumour suppression. |
| Databáze: | OpenAIRE |
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