Systematic genetic analysis of early-onset gout: ABCG2 is the only associated locus
| Autor: | Fernando Perez-Ruiz, Alexander So, Anne-Katherin Tausche, Fina A S Kurreeman, Philip Riches, Amanda Phipps-Green, Geraldine M. McCarthy, Greg G. Gamble, Jeffrey N. Miner, Leo A. B. Joosten, Faseeh Zaidi, Ravi K. Narang, Nicola Dalbeth, T.L.Th.A. Jansen, Matthijs Janssen, Lisa K. Stamp, Tony R. Merriman, Michael Doherty, Mariano Andrés, Rosa J. Torres |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities Gout lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] Single-nucleotide polymorphism Logistic regression Polymorphism Single Nucleotide chemistry.chemical_compound Rheumatology Internal medicine ATP Binding Cassette Transporter Subfamily G Member 2 Humans Medicine Genetic Predisposition to Disease Pharmacology (medical) Age of Onset Genetic association Creatinine business.industry Tophus nutritional and metabolic diseases Odds ratio Symptom Flare Up medicine.disease Neoplasm Proteins Uric Acid Europe chemistry Female business Body mass index |
| Zdroj: | Rheumatology, 59, 2544-2549 Rheumatology, 59, 9, pp. 2544-2549 |
| ISSN: | 1462-0324 |
| Popis: | Objective The aim of this study was to examine whether serum urate-associated genetic variants are associated with early-onset gout. Methods Participants with gout in the Genetics of Gout in Aotearoa study with available genotyping were included (n = 1648). Early-onset gout was defined as the first presentation of gout Results In the Genetics of Gout in Aotearoa study, there were 638 (42.4%) participants with early-onset gout. The ABCG2 rs2231142 gout risk T-allele was present more frequently in participants with early-onset gout compared with the later-onset group. For the other SNPs tested, no differences in risk allele number were observed. In the allelic association analysis, the ABCG2 rs2231142 T-allele was associated with early-onset gout in unadjusted and adjusted models. Analysis of the replication cohorts confirmed the association of early-onset gout with the ABCG2 rs2231142 T-allele, but not with other serum urate-associated SNPs. In the meta-analysis, the odds ratio (95% CI) for early-onset gout for the ABCG2 rs2231142 T-allele was 1.60 (1.41, 1.83). Conclusion In contrast to other serum urate-raising variants, the ABCG2 rs2231142 T-allele is strongly associated with early-onset gout. |
| Databáze: | OpenAIRE |
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