The Use of Natural Fiber-Rich Food Product Is Safe and Reduces Aberrant Crypt Foci in a Pre-Clinical Model
| Autor: | Bruna Paola Murino Rafacho, Rodrigo Juliano Oliveira, Antônio Carlos Duenhas Monreal, Felipe Francisco Bittencourt Junior, Tainá da Silva Fleming de Almeida, Andréia Conceição Milan Brochado Antoniolli-Silva, Rafael Souza Maris, Elisvânia Freitas dos Santos, Gabriel Oliveira de Souza, Adrivanio Baranoski, Cândida Aparecida Leite Kassuya, Luane Aparecida do Amaral |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Dietary Fiber
Male 1 2-dimethylhydrazine Colorectal cancer Colon Toxicogenetics Crypt Physiology medicine.disease_cause dietary fibers Article chemistry.chemical_compound Medicine Animals chemoprevention TX341-641 Rats Wistar Carcinogen functional foods Nutrition and Dietetics business.industry Nutrition. Foods and food supply medicine.disease Animal Feed 1 2-Dimethylhydrazine Disease Models Animal chemistry Toxicity Cytokines aberrant crypt foci Inflammation Mediators business Colorectal Neoplasms Genotoxicity Food Science Aberrant crypt foci |
| Zdroj: | Nutrients, Vol 13, Iss 2708, p 2708 (2021) Nutrients Volume 13 Issue 8 |
| ISSN: | 2072-6643 |
| Popis: | Background: Colorectal cancer is a highly prevalent disease, requiring effective strategies for prevention and treatment. The present research aimed to formulate a natural fiber-rich food product (NFRFP) and to evaluate its safety, toxicogenetics, and effects on aberrant crypt foci induced by 1,2-dimethyl-hydrazine in a preclinical model. Methods: A total of 78 male Wistar rats were distributed in six experimental groups: negative control, positive control (1,2-Dimethylhydrazine—40 mg/Kg), and four groups fed with 10% NFRFP: NFRFP, pre-treatment protocol, simultaneous treatment, and post-treatment protocol. Results: The NFRFP was shown to be a good source of fibers and did not change biometric, biochemical, hematological, and inflammatory parameters, and did not induce signs of toxicity and genotoxicity/carcinogenicity. NFRFP exhibited a chemopreventive effect, in all protocols, with damage reduction (% DR) of 75% in the comet test. NFRFP reduced the incidence of aberrant crypt outbreaks by 49.36% in the post-treatment protocol. Conclusions: The results suggest the applicability of NFRFP in the human diet due to potential production at an industrial scale and easy technological application in different products, since it could be incorporated in food without altering or causing small changes in final product sensory characteristics. |
| Databáze: | OpenAIRE |
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