Dose fall-off during the treatment of thoracic spine metastasis with CyberKnife stereotactic body radiation therapy (SBRT)
| Autor: | Jiwei Li, Li Jianxiong, Ruigang Ge, Huaiwen Zhang, Wei Xu, Xiaoshen Wang, Zhong-jian Ju, Jingyuan Wang, Qingzeng Zheng, Lei Du |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Thoracic spine Stereotactic body radiation therapy CyberKnife New and Emerging Methods stereotactic body radiation therapy Radiosurgery dosage Thoracic Vertebrae Metastasis Cohort Studies 03 medical and health sciences 0302 clinical medicine Cyberknife thoracic spine metastasis Medicine Humans Aged lcsh:R5-920 SBRT Spinal Neoplasms business.industry SBRT thoracic spine metastasis dose gradient Carcinoma Dose fractionation General Medicine Middle Aged medicine.disease Spinal cord Vertebra radiation medicine.anatomical_structure Treatment Outcome 030220 oncology & carcinogenesis Thoracic vertebrae Female Dose Fractionation Radiation lcsh:Medicine (General) business Nuclear medicine 030217 neurology & neurosurgery |
| Zdroj: | Bosnian Journal of Basic Medical Sciences Bosnian Journal of Basic Medical Sciences (2018) |
| ISSN: | 1840-4812 1512-8601 |
| Popis: | CyberKnife stereotactic body radiation therapy (SBRT) is becoming increasingly used for cancer treatment and, to maximize its clinical application, it is important to define the dosimetric characteristics, optimal dose and fractionation regimens. The aim of this study was to evaluate the dose fall-off in two fractionated regimens of CyberKnife SBRT during the treatment of thoracic spinal metastasis. Patients with spinal metastasis involving a vertebra and pedicle were treated with 40 Gy in 5 fractions (n = 4), and patients with spinal metastasis involving only a vertebra received 33 Gy in 3 fractions (n = 4). A new approach was used to measure absolute dose fall-off distance, relative dose fall-off distance, and the dose fall-off per unit distance along four reference directions in the axial plane. Patients treated with 33 Gy/3 fractions had a greater absolute dose fall-off distance in direction 1 (from the point with maximum dose [Dmax] towards the spinal cord) and direction 3 (the opposite of the direction 1), a greater relative dose fall-off distance in direction 3, and a lower dose fall-off per unit distance in direction 1 and 3 compared to patients treated with 40 Gy/5 fractions (all p < 0.05). Overall, the dose fall-off towards the spinal cord is rapid during the treatment of thoracic spinal metastasis with CyberKnife SBRT, which allows a higher dose of radiation to be delivered to the tumor and, at the same time, better protection of the spinal cord. |
| Databáze: | OpenAIRE |
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