Historical Perspectives and Advances in Mesenchymal Stem Cell Research for the Treatment of Liver Diseases
Autor: | Chien Wei Lee, Hao Hsiang Wu, Oscar K. Lee, Yu Fan Chen |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty medicine.medical_treatment Clinical uses of mesenchymal stem cells Liver transplantation Biology Mesenchymal Stem Cell Transplantation Regenerative Medicine History 21st Century End Stage Liver Disease 03 medical and health sciences medicine Humans Induced pluripotent stem cell Stem cell transplantation for articular cartilage repair Hepatology Mesenchymal stem cell Gastroenterology History 20th Century Liver Regeneration Transplantation 030104 developmental biology Hepatocytes Cancer research Liver function Stem cell |
Zdroj: | Gastroenterology. 154:46-56 |
ISSN: | 0016-5085 |
Popis: | Liver transplantation is the only effective therapy for patients with decompensated cirrhosis and fulminant liver failure. However, due to a shortage of donor livers and complications associated with immune suppression, there is an urgent need for new therapeutic strategies for patients with end-stage liver diseases. Given their unique function in self-renewal and differentiation potential, stem cells might be used to regenerate damaged liver tissue. Recent studies have shown that stem cell-based therapies can improve liver function in a mouse model of hepatic failure. Moreover, acellular liver scaffolds seeded with hepatocytes produced functional bioengineered livers for organ transplantation in preclinical studies. The therapeutic potential of stem cells or their differentiated progenies will depend on their capacity to differentiate into mature and functional cell types after transplantation. It will also be important to devise methods to overcome their genomic instability, immune reactivity, and tumorigenic potential. We review directions and advances in the use of mesenchymal stem cells and their derived hepatocytes for liver regeneration. We also discuss the potential applications of hepatocytes derived from human pluripotent stem cells and challenges to using these cells in treating end-stage liver disease. |
Databáze: | OpenAIRE |
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