The effect of cyclazocine on the cardiovascular responses to pressor and depressor amines in the rat
| Autor: | Gary D. Russi, F. Gene Martin |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
Chronotropic medicine.medical_specialty Sympathetic nervous system Epinephrine Tyramine Adrenergic Blood Pressure In Vitro Techniques Norepinephrine (medication) Hydroxydopamines Norepinephrine Phenylephrine chemistry.chemical_compound Heart Rate Internal medicine medicine Animals Cyclazocine Drug Interactions Heart Atria Amines Pharmacology Analysis of Variance Angiotensin II Isoproterenol Drug Synergism Stimulation Chemical Rats Carotid Arteries Endocrinology medicine.anatomical_structure chemistry circulatory and respiratory physiology medicine.drug |
| Zdroj: | European Journal of Pharmacology. 24:321-328 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(73)90157-x |
| Popis: | In anesthetized rats, cyclazocine potentiated the pressor responses to norepinephrine, epinephrine, tyramine and phenylephrine. Neither the depressor responses to isoproterenol nor the pressor resposes to angiotensin were potentiated by cyclazocine. In pithed and adrenalectomized rats, cyclazocine potentiated the pressor responses to norepinephrine. Chemical sympathectomy abolished the cyclazocine-induced potentiation of pressor responses to norepinephrine. In isolated rat atria, cyclazocine potentiated the chronotropic action of norepinephrine but did not alter the response to isoproterenol. It is suggested that cyclazocine causes potentiation of the agonistic properties of the various amines by interacting with the sympathetic nervous system, possibly by inhibiting the uptake of the amines into adrenergic nerve terminals. |
| Databáze: | OpenAIRE |
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