A first Czech analysis of 1887 cases with monoclonal gammopathy of undetermined significance

Autor:	Sabina Ševčíková, Zdeněk Adam, I. Vonke, Aneta Mikulasova, Jiří Jarkovský, Marta Krejčí, Vladimir Maisnar, Jarmila Obernauerova, Ivan Spicka, Lenka Zahradová, Petr Kessler, Luděk Pour, Viera Sandecká, Lucie Říhová, Vlastimil Scudla, Zdeněk Král, Dagmar Adamova, L. Walterová, Lucie Brožová, Jiří Minařík, Roman Hájek, Kamila Valentova, Jan Straub, Evžen Gregora, David Starostka, Jakub Radocha, Marek Wrobel
Rok vydání:	2017
Předmět:	Male medicine.medical_specialty Plasma Cells Kaplan-Meier Estimate Gastroenterology Monoclonal Gammopathy of Undetermined Significance Risk Assessment 03 medical and health sciences 0302 clinical medicine Bone Marrow Risk Factors Gammopathy Cytology Internal medicine medicine Humans Registries Pathological Multiple myeloma In Situ Hybridization Fluorescence Aged Czech Republic Proportional Hazards Models Aged 80 and over Malignant Conversion business.industry Hematology General Medicine Middle Aged medicine.disease 3. Good health medicine.anatomical_structure Cell Transformation Neoplastic Myeloma Proteins 030220 oncology & carcinogenesis Population Surveillance Monoclonal Disease Progression Female Bone marrow business Monoclonal gammopathy of undetermined significance Biomarkers 030215 immunology
Zdroj:	European journal of haematology. 99(1)
ISSN:	1600-0609
Popis:	IntroductionMonoclonal gammopathy of undetermined significance (MGUS) is a premalignant condition with a risk of malignant conversion. Patients and methodsWith the aim to estimate the cumulative risk MGUS progression to hematologic malignancies, we analyzed a nationwide population-basedcohort of 1887 MGUS patients from the Czech Registry of Monoclonal Gammopathies (RMG) between 2007 and 2013. ResultsDuring the follow-up period (median 4years; range 0.6-34.8), progression to hematologic malignancies was observed in 8.6% (162 of 1887) of patients. Factors associated with progression were as follows: M-protein concentration 1.5g/dL, pathological sFLC ( 1.65) ratio, bone marrow plasma cells (BMPCs) in cytology >5%, immunoparesis, age 69years, and the level of serum hemoglobin at baseline
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deea28f5690db5edeff15ceacf3fbf9a https://pubmed.ncbi.nlm.nih.gov/28384387 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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