Decreased Alpha Reactivity from Eyes-Closed to Eyes-Open in Non-Demented Older Adults with Alzheimer’s Disease: A Combined EEG and [18F]florbetaben PET Study
| Autor: | Dong Young Lee, Dahyun Yi, Hye Won Suk, Gi Hwan Byeon, Hongyoon Choi, Soohyun Chae, Jun Ho Lee, Jee Eun Park, Min Soo Byun, Jinsick Park |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Apolipoprotein E Fluorine Radioisotopes medicine.medical_specialty Alpha (ethology) Electroencephalography Eye Lateralization of brain function 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Internal medicine Stilbenes Humans Medicine Dementia Ocular Physiological Phenomena Florbetaben Aged Aged 80 and over Aniline Compounds medicine.diagnostic_test business.industry General Neuroscience General Medicine medicine.disease Hyperintensity Alpha Rhythm Psychiatry and Mental health Clinical Psychology 030104 developmental biology Positron-Emission Tomography Laterality Cardiology Female Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 77:1681-1692 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-200442 |
| Popis: | Background: The degree of alpha attenuation from eyes-closed (EC) to eyes-open (EO) has been suggested as a neural marker of cognitive health, and its disruption has been reported in patients with clinically defined Alzheimer’s disease (AD) dementia. Objective: We tested if EC-to-EO alpha reactivity was related to cerebral amyloid-β (Aβ) deposition during the early stage of AD. Methods: Non-demented participants aged ≥55 years who visited the memory clinic between March 2018 and June 2019 (N = 143; 67.8% female; mean age±standard deviation, 74.0±7.6 years) were included in the analyses. Based on the [18F]florbetaben positron emission tomography assessment, the participants were divided into Aβ+ (N = 70) and Aβ- (N = 73) groups. EEG was recorded during the 7 min EC condition followed by a 3 min EO phase, and a Fourier transform spectral analysis was performed. Results: A significant three-way interaction was detected among Aβ positivity, eye condition, and the laterality factor on alpha-band power after adjusting for age, sex, educational years, global cognition, depression, medication use, and white matter hyperintensities on magnetic resonance imaging (F = 5.987, p = 0.016); EC-to-EO alpha reactivity in the left hemisphere was significantly reduced in Aβ+ subjects without dementia compared with the others (F = 3.984, p = 0.048). Conclusion: Among mild cognitive impairment subjects, alpha reactivity additively contributed to predict cerebral Aβ positivity beyond the clinical predictors, including vascular risks, impaired memory function, and apolipoprotein E ɛ4. These findings support that EC-to-EO alpha reactivity acts as an early biomarker of cerebral Aβ deposition and is a useful measurement for screening early-stage AD. |
| Databáze: | OpenAIRE |
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