Metabolism of N-isopropylacetanilide in rat
| Autor: | J. E. Bakke, V J Feil, Gerald L. Larsen |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Pharmacology
Male Chromatography Health Toxicology and Mutagenesis Metabolite General Medicine Urine Metabolism Toxicology Biochemistry Acetaminophen Rats Rats Sprague-Dawley chemistry.chemical_compound chemistry Oral administration medicine Animals Acetanilides Propachlor Acetanilide Enterohepatic circulation medicine.drug |
| Zdroj: | Xenobiotica; the fate of foreign compounds in biological systems. 30(12) |
| ISSN: | 0049-8254 |
| Popis: | 1. Radioactivity from oral doses of N-isopropyl[1-14C]acetanilide was excreted in urine (53.5%), faeces (8.1%) and expired air (17.0%) of rat. 2. Enterohepatic circulation occurred during formation of approximately 34% of the metabolites. N-isopropylacetanilide was metabolized by oxidation in all moieties of the molecule with subsequent conjugation with glucuronic and sulphuric acids. 3. The sulphate ester of 4'-hydroxyacetanilide (acetaminophen) was the major metabolite (28 % of the dose). |
| Databáze: | OpenAIRE |
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