Role of IL28B gene polymorphism and cell-mediated immunity in spontaneous resolution of acute hepatitis C
| Autor: | Paola Perrone, Lucio Cosco, Caterina De Stefano, Maria Luisa Esposito, Giuseppe Maio, Vincenzo Mellace, Mario Cuccia, Maria Elena Tosti, Paola Del Porto, Gloria Taliani, Alessandra Vitelli, Salvatore Buonocore, Anna Rosa Garbuglia, Enea Spada, Gabriella Girelli, Gennaro Lettieri, Cristiano Scottà, Ruggiero Francavilla, Antonella Folgori, Paola Pierri, Luca Laurenti, Piergiorgio Chiriacò, Ubaldo Baldi, Corrado Mariano, Maria Rosaria Capobianchi, P. Amoroso, Alfredo Nicosia, Teresa Ferraro, Giulia Audino, Alfonso Mele, Franco Montesano, Antonio Caterini, Riccardo Cortese, Ornella Zuccaro, Roberto Rinaldi, Paola Scognamiglio, Enza Piccolella, Patrizia Maio, Pietro Bellissima |
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| Rok vydání: | 2013 |
| Předmět: |
Microbiology (medical)
Adult Male Hepatitis C virus medicine.disease_cause Polymorphism Single Nucleotide Liver disease Immunity medicine SNP cell-mediated immunity Humans Prospective Studies Prospective cohort study Articles and Commentaries Aged acute hepatitis C business.industry Interleukins prognostic factors virus diseases Hepatitis C Middle Aged medicine.disease Prognosis interleukin-28B digestive system diseases Infectious Diseases Interleukin 28B Italy acute hepatitis C cell-mediated immunity interleukin-28B prognostic factors Immunology Acute Disease Multivariate Analysis Female Gene polymorphism Interferons business |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 57(6) |
| ISSN: | 1537-6591 |
| Popis: | A single-nucleotide polymorphism (SNP; rs12979860) near the IL28B gene has been associated with spontaneous and treatment-induced hepatitis C virus clearance. We investigated predictors of spontaneous disease resolution in a cohort of patients with acute hepatitis C (AHC), analyzing epidemiological, clinical and virological parameters together with IL28B.rs12979860 genotypes and cell-mediated immunity (CMI). Fifty-six symptomatic AHC patients were enrolled and followed prospectively. CMI was measured in 31 patients at multiple time points by interferon-γ enzyme-linked immunospot assay and was correlated to the IL28B.rs12979860 SNP. Eighteen patients had a self-limiting AHC that was associated with female sex (P = .028), older age (P = .018), alanine aminotransferase level1000 U/L (P = .027), total bilirubin level7 mg/dL (P = .036), and IL28B.rs12979860 genotype CC (P = .030). In multivariate analysis, only CC genotype was independently associated with self-limiting AHC (odds ratio, 5.3; 95% confidence interval, 1.1-26.5). Patients with the CC genotype with self-limiting AHC had a stronger (P = .02) and broader (P = .013) CMI than patients with the CT genotype with chronically evolving AHC. In patients with chronically evolving disease, CC genotype was associated with a broader CMI compared to CT genotype (P = .028). A negative CMI was more frequently associated with CT genotype among persistently infected patients (P = .043) and with persistent infection among CT patients (P = .033).. Self-limiting AHC was independently associated with CC genotype. The correlation between IL28B.rs12979860 genotypes and CMI is suggestive of a possible important role of CMI in favoring hepatitis C virus clearance in CC patients. |
| Databáze: | OpenAIRE |
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