Plasma insulin levels predict atherosclerotic lesion burden in obese hyperlipidemic mice
| Autor: | Alli M. Nuotio-Antar, Viswanathan Saraswathi, Kimberly R. Coenen, Michelle R. Plummer, Alyssa H. Hasty, Marnie L. Gruen |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Apolipoprotein E
Very low-density lipoprotein medicine.medical_specialty medicine.medical_treatment Cholesterol VLDL Hyperlipidemias Biology Severity of Illness Index Gas Chromatography-Mass Spectrometry Lesion chemistry.chemical_compound Mice NEFA Insulin resistance Internal medicine medicine Animals Insulin Obesity Cholesterol Cholesterol HDL Cholesterol LDL medicine.disease Atherosclerosis Prognosis Mice Inbred C57BL Disease Models Animal Endocrinology chemistry lipids (amino acids peptides and proteins) medicine.symptom Insulin Resistance Cardiology and Cardiovascular Medicine Ultracentrifugation Biomarkers Lipoprotein |
| Zdroj: | Atherosclerosis. 186(1) |
| ISSN: | 0021-9150 |
| Popis: | Despite a clear association between obesity, insulin resistance and atherosclerosis in humans, to date, no animal models have been described in which insulin resistance is associated with atherosclerotic lesion burden. Using two mouse models of obesity-induced hyperlipidemia:leptin deficient (ob/ob) mice on an apolipoprotein E deficient (apoE-/-) or low density lipoprotein receptor deficient (LDLR-/-) background, we sought to determine metabolic parameters most closely associated with atherosclerotic lesion burden. Total plasma cholesterol (TC) levels in ob/ob;apoE-/- mice and ob/ob;LDLR-/- mice were indistinguishable (682+/-48 versus 663+/-16, respectively). Analysis of lipoprotein profiles showed that cholesterol was carried primarily on VLDL in the ob/ob;apoE-/- mice and on LDL in the ob/ob;LDLR-/- mice. Plasma triglycerides (TG) were 55% lower (P |
| Databáze: | OpenAIRE |
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