Pseudo five-component synthesis of 2,5-di(hetero)arylthiophenes via a one-pot Sonogashira-Glaser cyclization sequence
| Autor: | Dragutin Antovic, Dominik Urselmann, Thomas Müller |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Chemistry
Component (thermodynamics) multicomponent reactions Organic Chemistry C–C coupling chemistry.chemical_element Sonogashira coupling Sequence (biology) palladium Full Research Paper Catalysis lcsh:QD241-441 C c coupling chemistry.chemical_compound lcsh:Organic chemistry thiophenes copper Thiophene Organic chemistry lcsh:Q lcsh:Science Palladium |
| Zdroj: | Beilstein Journal of Organic Chemistry Beilstein Journal of Organic Chemistry, Vol 7, Iss 1, Pp 1499-1503 (2011) |
| ISSN: | 1860-5397 |
| Popis: | Based upon a consecutive one-pot Sonogashira–Glaser coupling–cyclization sequence a variety of 2,5-di(hetero)arylthiophenes were synthesized in moderate to good yields. A single Pd/Cu-catalyst system, without further catalyst addition, and easily available, stable starting materials were used, resulting in a concise and highly efficient route for the synthesis of the title compounds. This novel pseudo five-component synthesis starting from iodo(hetero)arenes is particularly suitable as a direct access to well-defined thiophene oligomers, which are of peculiar interest in materials science. |
| Databáze: | OpenAIRE |
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