Updates in rare and not-so-rare complications of acromegaly: focus on respiratory function and quality of life in acromegaly
| Autor: | Maria Fleseriu, Gabriela M Suarez, Fabienne Langlois |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Excessive growth
growth hormone excess medicine.medical_specialty patients reported outcome 030209 endocrinology & metabolism Review Disease General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Sleep Apnea Syndromes Quality of life Growth hormone excess Acromegaly medicine Humans Respiratory function In patient General Pharmacology Toxicology and Pharmaceutics Intensive care medicine General Immunology and Microbiology business.industry Respiration Sleep apnea Articles General Medicine sleep apnea medicine.disease 030220 oncology & carcinogenesis respiratory complication Quality of Life business |
| Zdroj: | F1000Research |
| ISSN: | 2046-1402 |
| Popis: | Acromegaly is a complex disease with excessive growth hormone and insulin-like growth factor 1 (IGF-1) causing multisystem effects, particularly cardiovascular, respiratory, and metabolic. Psychological concerns and poor quality of life (QoL) are also major disease consequences. This review is intended for clinicians and focuses on the latest developments related to respiratory and QoL effects of long-term growth hormone excess. Along with biochemical disease control, patient treatment satisfaction and outcomes have become major treatment objectives; current knowledge and tools to evaluate and manage this aspect of the disease are described. Sleep apnea syndrome and other derangements of lung function and apparatus, from pathophysiology to treatment, and evaluation tools and determinants of QoL in patients with acromegaly are discussed. |
| Databáze: | OpenAIRE |
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