Relationship of ALDH2 rs671 and CYP2E1 rs2031920 with hepatocellular carcinoma susceptibility in East Asians: a meta-analysis
| Autor: | Jihao Tu, Junhong Chen, Li-Jia Wen, Weicong Pan, Yongjin Chen, Kai Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Carcinoma Hepatocellular Genotype Hepatocellular carcinoma MEDLINE lcsh:Surgery Subgroup analysis lcsh:RC254-282 Asian People Internal medicine medicine Humans CYP2E1 Polymorphism Genetic Association Studies ALDH2 Polymorphism Genetic business.industry Research Aldehyde Dehydrogenase Mitochondrial Liver Neoplasms Cytochrome P-450 CYP2E1 Publication bias Odds ratio lcsh:RD1-811 medicine.disease Prognosis lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Confidence interval Meta-analysis Surgery business |
| Zdroj: | World Journal of Surgical Oncology, Vol 18, Iss 1, Pp 1-12 (2020) World Journal of Surgical Oncology |
| ISSN: | 1477-7819 |
| Popis: | Background Aldehyde dehydrogenase 2 (ALDH2) and cytochrome p450 2E1 (CYP2E1) are important alcohol-metabolizing enzymes. The aim of this meta-analysis was to evaluate the association of ALDH2 rs671 and CYP2E1 rs2031920 polymorphisms with hepatocellular carcinoma (HCC) susceptibility in East Asians. Methods A systematic search strategy was implemented in MEDLINE, PubMed, Scopus, Embase, and China Academic Journals databases. Nineteen case-control studies were selected for inclusion. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated through random-effects or fixed-effects models. Subgroup analysis, meta-regression, sensitivity analysis, cumulative meta-analysis, and evaluation of publication bias were performed. Results The overall meta-analysis did not find a significant association of ALDH2 rs671 and CYP2E1 rs2031920 genotypes with HCC susceptibility in East Asians. In addition, stratified analysis by country, Hardy-Weinberg equilibrium status, and source of controls also did not identify any association. Conclusion The ALDH2 rs671 and CYP2E1 rs2031920 polymorphisms are not associated with HCC susceptibility in East Asians. |
| Databáze: | OpenAIRE |
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