The Translational Genetics of Adhd and Related Phenotypes in Model Organisms
| Autor: | Judit Cabana-Domínguez, Ester Antón-Galindo, Noèlia Fernàndez-Castillo, Euginia L. Singgih, Aet O’Leary, William HG Norton, Tatyana Strekalova, Annette Schenck, Andreas Reif, Klaus-Peter Lesch, David Slattery, Bru Cormand |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
Trastorns per dèficit d'atenció amb hiperactivitat en els infants
Zebra danio Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] Peix zebra Cognitive Neuroscience Epigenètica Rosegadors Rodents Attention deficit disorder with hyperactivity in children Behavioral Neuroscience Neuropsychology and Physiological Psychology All institutes and research themes of the Radboud University Medical Center Trastorns per dèficit d'atenció amb hiperactivitat en els adults Attention deficit disorder with hyperactivity in adults Epigenetics |
| Zdroj: | Neuroscience and Biobehavioral Reviews, 144 Neuroscience and Biobehavioural Review |
| ISSN: | 0149-7634 |
| DOI: | 10.1016/j.neubiorev.2022.104949 |
| Popis: | Contains fulltext : 290890.pdf (Publisher’s version ) (Open Access) Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental disorder resulting from the interaction between genetic and environmental risk factors. It is well known that ADHD co-occurs frequently with other psychiatric disorders due, in part, to shared genetics factors. Although many studies have contributed to delineate the genetic landscape of psychiatric disorders, their specific molecular underpinnings are still not fully understood. The use of animal models can help us to understand the role of specific genes and environmental stimuli-induced epigenetic modifications in the pathogenesis of ADHD and its comorbidities. The aim of this review is to provide an overview on the functional work performed in rodents, zebrafish and fruit fly and highlight the generated insights into the biology of ADHD, with a special focus on genetics and epigenetics. We also describe the behavioral tests that are available to study ADHD-relevant phenotypes and comorbid traits in these models. Furthermore, we have searched for new models to study ADHD and its comorbidities, which can be useful to test potential pharmacological treatments. 01 januari 2023 |
| Databáze: | OpenAIRE |
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Full Text from ScienceDirect