Exercise-Mediated Browning of White Adipose Tissue: Its Significance, Mechanism and Effectiveness

Autor: Min Chen, Jie-Ying Zhu, Liang Guo, Wang-Jing Mu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Succinic Acid
Adipose tissue
Review
White adipose tissue
Ketone Bodies
Nervous System
Adipose Tissue
Brown
browning of WAT
Browning
Medicine
Homeostasis
Biology (General)
Spectroscopy
metabolites
exercise
food and beverages
ROS
General Medicine
Computer Science Applications
Exercise Therapy
Chemistry
lipids (amino acids
peptides
and proteins)
Fat loss
hormones
hormone substitutes
and hormone antagonists
medicine.medical_specialty
Ucp1
QH301-705.5
Adipose Tissue
White
Lipolysis
exerkines
SNS
Models
Biological
Catalysis
Fat mass
Inorganic Chemistry
Internal medicine
Animals
Humans
Lactic Acid
Obesity
Physical and Theoretical Chemistry
Molecular Biology
QD1-999
business.industry
Mechanism (biology)
Organic Chemistry
nutritional and metabolic diseases
medicine.disease
Endocrinology
business
Energy Metabolism
Reactive Oxygen Species
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 11512, p 11512 (2021)
International Journal of Molecular Sciences
ISSN: 1661-6596
1422-0067
Popis: As a metabolic organ, adipose tissue plays an important role in regulating metabolism. In adults, most adipose tissue is white adipose tissue (WAT), and excessive expansion of WAT will lead to obesity. It is worth noting that exercise can reduce the fat mass. There is also a lot of evidence that exercise can promote the browning of WAT, which is beneficial for metabolic homeostasis. Multiple factors, including reactive oxygen species (ROS), metabolites, nervous system, exerkines and lipolysis can facilitate exercise-mediated browning of WAT. In this review, the roles and the underlying mechanisms of exercise-mediated browning of WAT are summarized. The effects of different styles of exercise on the browning of WAT are also discussed, with the aim to propose better exercise strategies to enhance exercise-mediated browning of WAT, so as to promote metabolic health. Finally, the different reactivity of WAT at different anatomical sites to exercise-mediated browning is reviewed, which may provide potential suggestion for people with different fat loss needs.
Databáze: OpenAIRE
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