Colon-specific delivery of R68070, a new thromboxane synthase inhibitor, using chitosan capsules: Therapeutic effects against 2,4,6-trinitrobenzene sulfonic acid-induced ulcerative colitis in rats
| Autor: | Akira Terabe, Chiyuki Tanaka, Susumu Okabe, Shozo Muranishi, Takuya Fujita, Tomokazu Odoriba, Hideyuki Tozaki, Tsutomu Suzuki, Akira Yamamoto |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Colon Pyridines Capsules Chitin macromolecular substances Pharmacology General Biochemistry Genetics and Molecular Biology Dosage form Chitosan chemistry.chemical_compound Oral administration medicine Animals Rats Wistar General Pharmacology Toxicology and Pharmaceutics Pentanoic Acids Peroxidase biology Chemistry Therapeutic effect technology industry and agriculture Capsule General Medicine medicine.disease Ulcerative colitis digestive system diseases Rats Trinitrobenzenesulfonic Acid Biochemistry Myeloperoxidase biology.protein Colitis Ulcerative Thromboxane-A Synthase Thromboxane-A synthase |
| Zdroj: | Life Sciences. 64:1155-1162 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/s0024-3205(99)00044-2 |
| Popis: | The objective of this study was to estimate the therapeutic effects of R68070, a new thromboxane synthase inhibitor, on 2,4,6-trinitrobenzenesulfonic acid sodium salt (TNBS)-induced ulcerative colitis in rats. We also examined the acceleration of the healing effect of R68070 with chitosan capsules to achieve its colon-specific delivery. The colonic injury and inflammation were assessed by measuring the myeloperoxidase (MPO) activities, colon wet weight body weight ( C B ) ratio and the damage score, respectively. These markers were decreased by the oral administration of R68070 with chitosan capsules and carboxymethyl-cellulose (CMC) suspension. The therapeutic effects of R68070 against ulcerative colitis were observed in both dosage forms in a dose dependent manner. In addition, its therapeutic effects were increased by the use of chitosan capsules, compared with CMC suspension. These results suggest that chitosan capsule might be a very useful dosage form for the colon-specific delivery of R68070 as an anti-inflammatory drug and for the therapy of ulcerative colitis. |
| Databáze: | OpenAIRE |
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