Genotype distribution of human papillomavirus in women with abnormal cervical cytology in an esophageal carcinoma high incidence area of China
Autor: | Liangli Hong, Rui-Qin Mai, Ling Shen, Guo-Hong Zhang, Ying-Mu Cai, Bo Huang |
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Rok vydání: | 2014 |
Předmět: |
Adult
Cancer Research medicine.medical_specialty China Adolescent Esophageal Neoplasms Genotype Epidemiology Cytodiagnosis Uterine Cervical Neoplasms Young Adult Cytology medicine Carcinoma Prevalence Humans Human papillomavirus Normal cytology Papillomaviridae Aged Neoplasm Staging Retrospective Studies Gynecology Vaginal Smears business.industry Papillomavirus Infections Public Health Environmental and Occupational Health virus diseases Esophageal cancer Middle Aged medicine.disease Prognosis Uterine Cervical Dysplasia Oncology Abnormal cervical cytology DNA Viral Carcinoma Squamous Cell Female High incidence Neoplasm Grading business Follow-Up Studies |
Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 15(12) |
ISSN: | 2476-762X |
Popis: | Infection with human papillomavirus (HPV) could affect genesis of both cervical and esophageal cancers. The type-specific distribution of HPV in cervical cytology abnormalities of women has remained unclear in Shantou, an esophageal cancer high-incidence area of China. Data from 22,617 women who were subjected to cervical HPV DNA testing with simultaneous cervical cytological examination during 2009-2013 were therefore here retrospectively evaluated in a hospital-based study. Overall, 16.2% (3,584/22,114)of women with normal cytology were HR-HPV positive, with HPV-52 (4.07%) as the most common type followed by -16 (3.63%), and -58 (2.46%). Prevalence of HR-HPV was 50.3% (253/503) in women with cervical cytological abnormalities, of which in ASC-H 71.4%, ASC-US 39.1%, HSIL 80.3% and LSIL 73.7%. HPV-58 (14.12%) was the most common type for all cervical cytological abnormalities, followed by HPV-16 (13.72%), and -52 (12.72%), while the more common HPV-16 type in ASC-H (42.9%) and HSIL (36.1%), HPV-52 and -58 were the most common types for ASC-US (10.3%) and LSIL (25%), respectively. Multiple HPV co-infections were identified in 33.2% (84/253) cytology abnormalities with positive HR-HPV, and the highest prevalence of HPV-58/16 combination in HSIL (28.6%, 6/21) was observed. Our data indicated a relative high prevalence of HPV-58 and -52 in women with cervical cytological abnormalities, which should be considered in the development of next-generation vaccines for Shantou. |
Databáze: | OpenAIRE |
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