Cardiac Magnetic Resonance Myocardial Feature Tracking for Optimized Prediction of Cardiovascular Events Following Myocardial Infarction
| Autor: | Gerd Hasenfuß, Shelby Kutty, Holger Thiele, Andreas Schuster, Matthias Gutberlet, Johannes T. Kowallick, Thomas Stiermaier, Joachim Lotz, Ingo Eitel, Alexander Koschalka, Karl Philipp Rommel, Torben Lange |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Time Factors 030204 cardiovascular system & hematology Tracking (particle physics) Risk Assessment Ventricular Function Left 030218 nuclear medicine & medical imaging 03 medical and health sciences Percutaneous Coronary Intervention 0302 clinical medicine Text mining Predictive Value of Tests Risk Factors Germany Internal medicine Humans Medicine Radiology Nuclear Medicine and imaging Myocardial infarction Non-ST Elevated Myocardial Infarction Aged Randomized Controlled Trials as Topic business.industry Myocardium Myocardial feature Stroke Volume Middle Aged equipment and supplies medicine.disease Magnetic Resonance Imaging Myocardial Contraction Biomechanical Phenomena Treatment Outcome Multicenter study Risk stratification cardiovascular system Cardiology ST Elevation Myocardial Infarction Feature tracking Female Cardiology and Cardiovascular Medicine Cardiac magnetic resonance business human activities |
| Zdroj: | JACC: Cardiovascular Imaging. 11:1433-1444 |
| ISSN: | 1936-878X |
| DOI: | 10.1016/j.jcmg.2017.11.034 |
| Popis: | The aims of the study were to assess the prognostic significance of cardiac magnetic resonance myocardial feature tracking (CMR-FT) in a large multicenter study and to evaluate the most potent CMR-FT predictor of hard clinical events following myocardial infarction (MI).CMR-FT is a new method that allows accurate assessment of global and regional circumferential, radial, and longitudinal myocardial strain. The prognostic value of CMR-FT in patients with reperfused MI is unknown.The study included 1,235 MI patients (n = 795 with ST-segment elevation MI and 440 with non-ST-elevation MI) at 15 centers. All patients were reperfused by primary percutaneous coronary intervention. Central core laboratory-masked analyses were performed to determine left ventricular (LV) circumferential, radial, and longitudinal strain. The primary clinical endpoint of the study was the occurrence of major adverse cardiac events within 12 months after infarction.Patients with cardiovascular events had significantly impaired CMR-FT strain values (p 0.001 for all). Global longitudinal strain was identified as the strongest CMR-FT parameter of future cardiovascular events and emerged as an independent predictor of poor prognosis following MI even after adjustment for established prognostic markers. Global longitudinal strain provided an incremental prognostic value for all-cause mortality above LV ejection fraction (c-index increase from 0.65 to 0.73; p = 0.04) and infarct size (c-index increase from 0.60 to 0.78; p = 0.002).CMR-FT is a superior measure of LV function and performance early after reperfused MI with incremental prognostic value for mortality over and above LV ejection fraction and infarct size. (Abciximab i.v. Versus i.c. in ST-segment elevation Myocardial Infarction [AIDA STEMI]; NCT00712101; Thrombus Aspiration in ThrOmbus Containing culpRIT Lesions in Non-ST-Elevation Myocardial Infarction [TATORT-NSTEMI]; NCT01612312). |
| Databáze: | OpenAIRE |
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