Volatile oil of Croton zehntneri per oral sub-acute treatment offers small toxicity: perspective of therapeutic use
| Autor: | Kerly Shamyra da Silva-Alves, Keciany Alves de Oliveira, Yuri de Abreu Gomes Vasconcelos, JosÃc Henrique Leal-Cardoso, Maria Valdenir Abreu de Paula Rocha, Edgleyson Chaves dos Santos, Francisco Walber Ferreira-da-Silva, Andrelina Noronha Coelho-de-Souza, Lðcio Ricardo L. Diniz, JanaÃ-na Serra-Azul M. Evangelista, AriclÃccio C. Oliveira, Ana Maria Sampaio Assreuy, Edson Lopes da Ponte |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Volatile oil
lcsh:RS1-441 Sub acute 01 natural sciences lcsh:Pharmacy and materia medica chemistry.chemical_compound medicine General Pharmacology Toxicology and Pharmaceutics Anethole Kidney Toxicity biology Traditional medicine 010405 organic chemistry Euphorbiaceae biology.organism_classification Croton 0104 chemical sciences 010404 medicinal & biomolecular chemistry medicine.anatomical_structure chemistry Uric acid Estragole |
| Zdroj: | Revista Brasileira de Farmacognosia, Vol 29, Iss 2, Pp 228-233 (2019) Revista Brasileira de Farmacognosia v.29 n.2 2019 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA Revista Brasileira de Farmacognosia, Volume: 29, Issue: 2, Pages: 228-233, Published: 27 MAY 2019 |
| Popis: | Croton zehntneri Pax & K. Hoffm., Euphorbiaceae, or “canela-de-cunhé” is used in the Northeast Brazil to treat several diseases. Leaves and aerial parts of C. zehntneri are rich in volatile oil of high potential therapeutic. This study aimed to investigate volatile oil systemic toxicity after per oral treatment in rats. Volatile oil characterization (gas chromatography and mass spectrometry) showed 85.7% anethole and 4.8% estragole. Male Wistar rats (116–149 g) were treated with volatile oil (250 mg/kg p.o.) during ten weeks and evaluated for the following parameters: survival; food and water intake; body mass; absolute/relative organs weight; hemogram; plasma biochemical dosage; organs morphology. Volatile oil did not alter animal water and food consumption or the relative/absolute weight of most organs, but animals gained less weight. Volatile oil did not alter function biomarkers of pancreas, kidney, heart or liver, but increased plasma gamma-glutamyltranspeptidase (liver biomarker) and decreased uric acid (kidney biomarker). Although volatile oil had caused discrete morphological alterations in some organs, it did not induce architectural changes in these organs. In conclusion, the sub-acute per oral treatment with volatile oil no longer than ten weeks in rats offers small toxicity at doses below 250 mg/kg. Keywords: Anethole, Volatile oil, Euphorbiaceae, Toxicity |
| Databáze: | OpenAIRE |
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