von Willebrand Disease and other hereditary haemostatic factor deficiencies in women with a history of postpartum haemorrhage
| Autor: | Patricia Gomez-Rosas, Jesús Hernández-Juárez, Claudia C. Calzada-Mendoza, Rodrigo Arreola-Diaz, María Teresa García-Lee, Víctor Domínguez-Reyes, Anahi Guadalupe Figueroa-Torres, María Tania Ricardo-Moreno, Irma Isordia-Salas, Abraham Majluf-Cruz, Manuel Moreno-Hernández, Rosa Elena Sosa-Camas, Jaime García-Chávez, Liliana Anguiano-Robledo, Karim Majluf-Cruz, Jorge Vela Ojeda |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Coagulation Protein Disorders 030204 cardiovascular system & hematology Fibrinogen Hemostatics law.invention Young Adult 03 medical and health sciences 0302 clinical medicine Von Willebrand factor Pregnancy law medicine Von Willebrand disease Humans Genetics (clinical) biology business.industry Obstetrics Postpartum Hemorrhage Hematology General Medicine medicine.disease Postpartum haemorrhage Intensive care unit von Willebrand Diseases Increased risk biology.protein Female Liver function business 030215 immunology medicine.drug |
| Zdroj: | Haemophilia. 26:97-105 |
| ISSN: | 1365-2516 1351-8216 |
| Popis: | Introduction Postpartum haemorrhage (PPH) is the main cause of maternal morbidity and mortality globally, but it is far more important in non-developed countries. PPH represents 25% of all maternal deaths worldwide. Women with von Willebrand disease (VWD) and other inherited haemorrhagic disorders are at increased risk of PPH. Our aim was to establish a probable association of severe PPH in women with a history of haemostatic abnormalities. Methods An observational, controlled study of adult women with a one or more episodes of severe PPH requiring treatment in an intensive care unit or >10 units of blood products during the 24-hour period after diagnosis and their controls. The tests performed were blood cell count, blood group, renal, viral, liver function and haemostatic tests, fibrinogen, activity of the plasma factors and specific test to diagnose and classify VWD. Results We included 124 women with 133 PPH events and their controls. The median age at the first event was 25.5 years old. Results were significantly different between the groups in terms of fibrinogen concentration, VWF:Ag, VWF:RCo and FVIII. A specific diagnosis was established in 69 (55.6) and 4 (3.2%) patients in the PPH group and controls, respectively. Of 61 patients with VWD, 57 had type 1, two had type 2A, and another two had type 2B. Conclusion Our results show a relationship between PPH and inherited haemostatic disorders. VWD was the most frequent diagnosis. Appropriate and opportune diagnosis before pregnancy of inherited haemostatic disorders may be important to effectively prevent and treat PPH. |
| Databáze: | OpenAIRE |
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