The association between airflow limitation and blood eosinophil levels with treatment outcomes in patients with chronic obstructive pulmonary disease and prolonged mechanical ventilation
| Autor: | Pi-Chu Wu, Hui-Chen Chen, Wei-Chang Huang, Chen-Cheng Huang, Ming-Feng Wu, Ya-Hua Cheng, Jeng-Yuan Hsu, Ching-Hsiao Lee, Chao-Jung Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Population lcsh:Medicine Pulmonary disease Article 03 medical and health sciences Leukocyte Count Pulmonary Disease Chronic Obstructive 0302 clinical medicine Internal medicine Forced Expiratory Volume medicine Eosinophilia Weaning Humans In patient 030212 general & internal medicine lcsh:Science education Aged Retrospective Studies Mechanical ventilation Aged 80 and over education.field_of_study COPD Multidisciplinary business.industry lcsh:R Respiratory Center medicine.disease Respiration Artificial Obstructive lung disease Eosinophils Cross-Sectional Studies Treatment Outcome 030228 respiratory system Risk factors Outcomes research lcsh:Q Female medicine.symptom business |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-6 (2019) |
| ISSN: | 2045-2322 |
| Popis: | The clinical implications of airflow limitation severity and blood eosinophil level in patients with chronic obstructive pulmonary disease (COPD) and prolonged mechanical ventilation (PMV) are unknown. Thus, this study aimed to identify whether or not these two indicators were significantly associated with short-term in-respiratory care center (RCC) treatment outcomes in this population. Of all participants (n = 181) in this retrospective cross-sectional study, 41.4%, 40.9%, 8.3%, and 52.5% had prolonged RCC admission (RCC length of stay >21 days), failed weaning, death, and any adverse outcomes of interest, respectively. Compared to participants without any adverse outcomes of interest, moderate (the Global Initiative for Chronic Obstructive Lung Disease (GOLD) II) and/or severe (GOLD III) airflow limitation were significantly associated with short-term in-RCC adverse outcomes in terms of failed weaning (for III versus I, OR = 15.06, p = 0.003) and having any adverse outcomes of interest (for II versus I, OR = 17.66, p = 0.002; for III versus I, OR = 37.07, p = 0.000) though the severity of airflow limitation did not have associations with prolonged RCC admission and death after adjustment. Meanwhile, blood eosinophilia defined by various cut-off values was not associated with any adverse outcomes. The findings have significant clinical implications and are useful in the management of patients with COPD and PMV. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|