New triterpenoid saponins from the leaves of Ilex chinensis
| Autor: | Ruo-Fei Li, Shuai Li, Hua Sun, Wen-Qi Xia, Bao-Song Cui, Qi Hou, Jiabao Liu |
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| Rok vydání: | 2018 |
| Předmět: |
Ilex chinensis
Lipopolysaccharide Phytochemicals Ilex Aquifoliaceae Nitric Oxide Protective Agents 01 natural sciences chemistry.chemical_compound Mice Triterpenoid Drug Discovery Animals Humans No production Oleanolic Acid Pharmacology Traditional medicine Molecular Structure 010405 organic chemistry Chemistry Macrophages In vitro toxicology General Medicine Hep G2 Cells Saponins Triterpenes 0104 chemical sciences Plant Leaves 010404 medicinal & biomolecular chemistry Hepg2 cells Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Fitoterapia. 131 |
| ISSN: | 1873-6971 |
| Popis: | Eight new triterpenoid saponins, including four ursane-type saponins, ilexchinenosides J-M (1-4), and four oleanane-type saponins, ilexchinenosides N-Q (5-8), along with three known triterpenoid saponins (9-11) were isolated from the leaves of Ilex chinensis Sims. Their structures were established by 1D, 2D NMR and MS spectroscopic analyses and through comparisons with known compounds. Moreover, compounds 1, 3, 5, 7-9 and 11 exhibited significant levels of hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell damage in in vitro assays while compound 10 had moderately inhibitory effects on the NO production of lipopolysaccharide (LPS)-induced murine macrophages. |
| Databáze: | OpenAIRE |
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