The effect of hippocampal sympathetic ingrowth and cholinergic denervation on hippocampal M2 cholinergic receptors
| Autor: | Lindy E. Harrell, Dee S. Parsons, Krystyna Kolasa |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Sympathetic nervous system Sympathetic Nervous System Hippocampus Hippocampal formation Biology Binding Competitive Rats Sprague-Dawley Internal medicine Muscarinic acetylcholine receptor medicine Animals Molecular Biology Denervation General Neuroscience Muscarinic acetylcholine receptor M2 Receptors Muscarinic Rats medicine.anatomical_structure Endocrinology Cholinergic Fibers Cervical ganglia Cholinergic Neurology (clinical) Developmental Biology |
| Zdroj: | Brain Research. 684:201-205 |
| ISSN: | 0006-8993 |
| Popis: | After cholinergic denervation of the hippocampus, via medial septal (MS) lesions, peripheral sympathetic fibers, originating from the superior cervical ganglia, grow into the hippocampus. In this study, we sought to determine the effect of hippocampal sympathetic ingrowth (HSI) on the M 2 subtype of muscarinic cholinergic receptors, by examining the membrane bindingo of [ 3 H]AF-DX 384 in hippocampal tissue from control rats, rats with HSI and rats with MS lesions+ concurrent ganglionectomy (CD group). In dorsal hippocampus, K d was found to be increased while B max was decreased in the CD group as compared with both the HSI and control group which did not differ from one another. In ventral hippocampus, K d was found to be increased while B max was decreased in the CD group when compared only with the control group. These results suggest that sympathetic ingrowth, which has its greatest concentration in dorsal hippocampus, can ‘normalize’ the M 2 receptor in hippocampus. |
| Databáze: | OpenAIRE |
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