Low baseline proBNP associated with increased risk of intraoperative hypotension during spinal anaesthesia for cesarean delivery
| Autor: | Gultekin Genctoy, Tonguç Saba, Tayfun Birtay |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
NT-PROBNP lcsh:Medicine Hemodynamics Blood Pressure NORMAL-PREGNANCY Anesthesia Spinal Preeclampsia Random Allocation Heart Rate Pregnancy Natriuretic Peptide Brain Heart rate medicine Humans cardiovascular diseases Intraoperative Complications METAANALYSIS Body fluid Cesarean Section business.industry lcsh:R WOMEN Spinal anesthesia General Medicine medicine.disease Brain natriuretic peptide PROGNOSTIC VALUE PREECLAMPSIA Cross-Sectional Studies Blood pressure HEMODYNAMICS BRAIN NATRIURETIC PEPTIDE Anesthesia cardiovascular system Female Hypotension business NONCARDIAC SURGERY human activities hormones hormone substitutes and hormone antagonists BNP circulatory and respiratory physiology |
| Zdroj: | Annals of Saudi Medicine, Vol 35, Iss 3, Pp 248-253 (2015) |
| ISSN: | 0975-4466 0256-4947 |
| DOI: | 10.5144/0256-4947.2015.248 |
| Popis: | BACKGROUND AND OBJECTIVES: Brain natriuretic peptide (BNP) has a role in the regulation of body fluid volume and blood pressure (BP). BNP remains within a normal range during spinal anaesthesia (SA) in patients undergoing cesarean delivery. However, the effect of BNP on changes in BP during the perioperative period has not been evaluated. We aimed to investigate the effect of preoperative serum BNP on the risk of hypotension during cesarean delivery with SA. DESIGN AND SETTING: Patients were randomly selected among the patient group who were attending routine clinic visits for pregnancy monitoring. All had a healthy pregnancy and no other acute or chronic disease by their obstetrician. The study design was cross-sectional. PATIENTS AND METHODS: Patients who had uncomplicated pregnancy process and no known medical disease were selected consecutively during their last outpatient clinical examination. Baseline BP was recorded before SA. Simultaneously, blood samples were drawn for routine biochemistry and BNP. BP, SaO(2), and electro-cardiography were monitored during surgery. Intraoperative hypotension (IOH) was defined as >= 25% decrease in mean arterial pressure (MAP) at the 5th minute of SA. RESULTS: In 41 term pregnant women, 18 of the 41 patients (43.9%) fulfilled the criteria for IOH, while 23 (56.1%) showed a decrease 13.1 (11.3%) and were classified as normotensive. Baseline BNP was significantly lower in patients with IOH compared with normotensive patients 45.7 (26.9) vs. 70.2 (40.5); P=. 05. Baseline BNP had no significant correlation MAP at any time point. Age, body mass index, hemoglobin, baseline MAP and heart rate were not different between patients with and without IOH. CONCLUSION: Those findings suggest that higher baseline BNP levels might have a protective role in development of hypotension in healthy term pregnant women during SA for cesarean delivery. |
| Databáze: | OpenAIRE |
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