Continuous infusion of calcium gluconate in 5% albumin is safe and prevents most hypocalcemic reactions during therapeutic plasma exchange
| Autor: | Marisa B. Marques, Shu T. Huang, Suthida Kankirawatana |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Potassium chemistry.chemical_element Chronic inflammatory demyelinating polyneuropathy Calcium Guillain-Barre Syndrome Albumins Myasthenia Gravis Medicine Humans Infusions Intravenous biology Hypocalcemia Plasma Exchange business.industry Albumin Polyradiculoneuropathy Angiotensin-converting enzyme Hematology General Medicine medicine.disease Calcium Gluconate Myasthenia gravis Treatment Outcome chemistry Polyradiculoneuropathy Chronic Inflammatory Demyelinating Anesthesia Toxicity biology.protein Chlorates Female business |
| Zdroj: | Journal of clinical apheresis. 22(5) |
| ISSN: | 0733-2459 |
| Popis: | While therapeutic plasma exchanges (TPEs) performed with 5% albumin are considered safe, concerns regarding venous access and hypocalcemic toxicity remain. We reviewed the frequency of complications during TPEs performed with 5% albumin supplemented with calcium gluconate and potassium chloride for a 5 year period in our institution. Eighty-four adult patients (46 males and 38 females) underwent 581 plasma exchanges during the study period. The most common indications were myasthenia gravis (37%), acute inflammatory demyelinating polyradiculoneuropathy (31%), and chronic inflammatory demyelinating polyneuropathy (13%). All procedures used 2.2% ACD-A delivered at a calculated average rate of 0.26 mg/kg/min, which led to a mean dose of citrate per TPE of 2.18 +/- 0.48 g or 27.8 +/- 5.24 mg/kg of body weight. Venous access difficulties occurred in 85 procedures (14.6%), but most TPEs were completed successfully. Hypotension and citrate toxicity were seen in |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text