Variability of Botulinum Toxins: Challenges and Opportunities for the Future

Autor: Christine Rasetti-Escargueil, Michel R. Popoff, Emmanuel Lemichez
Přispěvatelé: Toxines bactériennes - Bacterial Toxins, Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Botulinum Toxins
Health
Toxicology and Mutagenesis
MESH: Botulinum Toxins/toxicity
[SDV]Life Sciences [q-bio]
MESH: Neurotoxins/toxicity
Neurotoxins
lcsh:Medicine
Computational biology
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
[SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]
Review
Biology
botulinum neurotoxins (BoNTs)
Toxicology
MESH: Neurons/drug effects
Antibodies
03 medical and health sciences
0302 clinical medicine
BoNT variants
[SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]
Animals
Humans
MESH: Animals
Neurons
MESH: Humans
MESH: Antibodies
subtypes
lcsh:R
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
3. Good health
030104 developmental biology
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Biological warfare
Chimeric molecules
030217 neurology & neurosurgery
Zdroj: Toxins
Toxins, Vol 10, Iss 9, p 374 (2018)
Toxins, MDPI, 2018, 10 (9), pp.374. ⟨10.3390/toxins10090374⟩
Toxins, 2018, 10 (9), pp.374. ⟨10.3390/toxins10090374⟩
ISSN: 2072-6651
DOI: 10.3390/toxins10090374⟩
Popis: International audience; Botulinum neurotoxins (BoNTs) are the most potent known toxins, and are therefore classified as extremely harmful biological weapons. However, BoNTs are therapeutic drugs that are widely used and have an increasing number of applications. BoNTs show a high diversity and are divided into multiple types and subtypes. Better understanding of the activity at the molecular and clinical levels of the natural BoNT variants as well as the development of BoNT-based chimeric molecules opens the door to novel medical applications such as silencing the sensory neurons at targeted areas and dermal restoration. This short review is focused on BoNTs' variability and the opportunities or challenges posed for future clinical applications.
Databáze: OpenAIRE
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