Comparison of histologic lesions of endophthalmitis induced by Blastomyces dermatitidis in untreated and treated dogs: 36 cases (1986–2001)
| Autor: | Diane V. H. Hendrix, Barton W Rohrbach, Philip N. Bochsler, R V English |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Pathology medicine.medical_specialty Antifungal Agents Scoring system Ophthalmic examination Itraconazole Blastomycosis Dogs Endophthalmitis Lens Crystalline medicine Animals Dog Diseases Retrospective Studies General Veterinary biology Blastomyces dermatitidis medicine.disease biology.organism_classification Blastomyces Female medicine.drug |
| Zdroj: | Journal of the American Veterinary Medical Association. 224:1317-1322 |
| ISSN: | 0003-1488 |
| DOI: | 10.2460/javma.2004.224.1317 |
| Popis: | Objective—To compare prevalence of organisms and histologic changes in eyes from dogs with blastomycosis that were either untreated or undergoing treatment with itraconazole.Design—Retrospective study.Animals—36 dogs with endophthalmitis associated with blastomycosis.Procedure—Signalment, results of ophthalmic examination, and duration of treatment with itraconazole were extracted from medical records. Histologic sections from eyes were examined for prevalence and viability (ie, budding) of fungal organisms. A scoring system was devised to assess the degree of inflammation.Results—Clinically, all eyes were blind and had signs of severe endophthalmitis. Histologically, the type and degree of inflammation and prevalence ofBlastomyces dermatitidiswere not significantly different between dogs treated with itraconazole and untreated dogs or among groups of dogs treated for different time periods (4 to 14, 15 to 28, or 29 to 72 days). Replication of the organisms in vascular tissues as well as avascular spaces in the eyes was similar in treated and untreated dogs. Lens rupture was seen in 12 of 29 (41%) eyes.Conclusions and Clinical Relevance—Persistence of inflammation in eyes of dogs with naturally occurring blastomycosis is likely attributable to the continued presence ofB dermatitidis, regardless of the duration of treatment with itraconazole. Lens capsule rupture, a common and previously unreported histologic finding, may contribute to cataract formation and continued inflammation. (J Am Vet Med Assoc2004; 224:1317–1322) |
| Databáze: | OpenAIRE |
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