Assessing the impact of aging and blood pressure on dermal microvasculature by reactive hyperemia optical coherence tomography angiography
Autor: | Anne C. Kim, Weeranut Phothong, Garuna Kositratna, Joshua Glahn, Dieter Manstein, Tuanlian Luo, Michael Wang-Evers, Neera R. Nathan, Daniel Karasik, Abigail E. Doyle, Malte Casper, Tammy Heesakker |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Aging
Pathology genetic structures Blood Pressure Pilot Projects 030204 cardiovascular system & hematology 01 natural sciences Translational Research Biomedical 0302 clinical medicine Medicine Skin Aged 80 and over Multidisciplinary Angiography Pathophysiology Forearm Hypertension Disease Progression Female Medical imaging Perfusion Tomography Optical Coherence Adult medicine.medical_specialty Adolescent Science Hyperemia Article Microcirculation 010309 optics Vascular health Young Adult 03 medical and health sciences 0103 physical sciences Humans Reactive hyperemia Aged business.industry Optical coherence tomography angiography Translational research Skin manifestations Cardiovascular biology eye diseases Blood pressure Microvessels Histopathology sense organs business |
Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Visualization and quantification of the skin microvasculature are important for studying the health of the human microcirculation. We correlated structural and pathophysiological changes of the dermal capillary-level microvasculature with age and blood pressure by using the reactive hyperemia optical coherence tomography angiography (RH-OCT-A) technique and evaluated both conventional OCT-A and the RH-OCT-A method as non-invasive imaging alternatives to histopathology. This observational pilot study acquired OCT-A and RH-OCT-A images of the dermal microvasculature of 13 young and 12 old healthy Caucasian female subjects. Two skin biopsies were collected per subject for histological analysis. The dermal microvasculature in OCT-A, RH-OCT-A, and histological images were automatically quantified and significant indications of vessel rarefaction in both old subjects and subjects with high blood pressure were observed by RH-OCT-A and histopathology. We showed that an increase in dermal microvasculature perfusion in response to reactive hyperemia was significantly lower in high blood pressure subjects compared to normal blood pressure subjects (117% vs. 229%). These results demonstrate that RH-OCT-A imaging holds functional information of the microvasculature with respect to physiological factors such as age and blood pressure that may help to monitor early disease progression and assess overall vascular health. Additionally, our results suggest that RH-OCT-A images may serve as a non-invasive alternative to histopathology for vascular analysis. |
Databáze: | OpenAIRE |
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