Individual differences in the effect of novel environmental stimuli prior to amphetamine self-administration in rats (Rattus norvegicus)
| Autor: | Michael T. Bardo, Mary E. Cain, William F. Dotson |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pharmacology
Male Motivation Amphetamines Novelty seeking Novelty Physiology Self Administration Biology Rats Rats Sprague-Dawley Psychiatry and Mental health Locomotor test Preference test Anesthesia medicine Maintenance phase Sensation seeking Animals Pharmacology (medical) Amphetamine Self-administration medicine.drug |
| Zdroj: | Experimental and clinical psychopharmacology. 14(3) |
| ISSN: | 1064-1297 |
| Popis: | These experiments determined whether individual differences in response to novelty subsequently predict the ability of novel stimuli, presented prior to the session, to decrease amphetamine self-administration. Using an inescapable locomotor test, the authors found that high-responder rats (Rattus norvegicus) showed a greater novelty-induced decrease in the acquisition of self-administration compared with low-responder rats. This effect was dose dependent and generalized to sucrose-reinforced responding. Using a free-choice place preference test, the authors found that high-novelty-seeking rats also showed a greater novelty-induced decrease in the acquisition of self-administration compared with low-novelty- seeking rats. Regardless of individual differences, novelty had little effect on amphetamine self-administration during the maintenance phase. These results suggest that exposure to novel environmental stimuli may reduce acquisition of drug-taking behavior, especially among high-novelty-seeking individuals. |
| Databáze: | OpenAIRE |
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