Long-term safety, efficacy, treatment satisfaction, and impact on healthcare service use of paliperidone palmitate one-month intramuscular formulation in patients with recent-onset schizophrenia in taiwan: A subgroup analysis of an asia-pacific, 18-month, phase 3b study
| Autor: | Tung Ping Su, Nan-Ying Chiu, Chih-Lin Chiang, Tze-Chun Tang, Ming-Hong Hsieh, Chen-Chung Liu, Fong-Lin Jang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Paliperidone Palmitate
Psychiatry medicine.medical_specialty Positive and Negative Syndrome Scale business.industry long-acting injection RC435-571 Subgroup analysis clinical trial medicine.disease Treatment efficacy Clinical trial schizophrenia Schizophrenia Internal medicine medicine In patient employment status Healthcare service business |
| Zdroj: | Taiwanese Journal of Psychiatry, Vol 33, Iss 4, Pp 198-203 (2019) |
| ISSN: | 2666-2078 1028-3684 |
| Popis: | Objectives: In this study, the authors intended to evaluate the efficacy and safety of paliperidone palmitate 1-month injection (PP1M) in patients with recent-onset schizophrenia (SCH). Methods: A subgroup analysis was done for patients enrolled in Taiwan in an Asia-Pacific, Phase 3b study (ClinicalTrials.gov identifier NCT01051531). Patients were switched from oral antipsychotics to intramuscular PP1M. Results: We included 61 patients (age: 31.2 ± 8.8 years). The Positive and Negative Syndrome Scale scores were significantly decreased, with the largest effect size observed in positive, disorganized, and depressive factors (Cohen's d = 0.52, 0.52, and 0.79, respectively). Most symptoms stabilized within six months, whereas stabilization of functional improvement required 1–1.5 years of PP1M treatment, especially for employment/academic status. PP1M treatment was well-tolerated, with over 70% of treatment satisfaction rate, and significantly reduced the average days of hospitalization (43.3–7.1/person-years). Conclusion: Switching to PP1M improved treatment outcome and satisfaction as well as reduced healthcare service use in patients with recent-onset SCH. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|