Twenty-four-hour intragastric acidity and plasma gastrin during 3-month treatment with omeprazole in healthy subjects
| Autor: | V. Wirquin, F. Roudot, L. Stanescu, Robert Benamouzig, Jean-Charles Delchier, D. Lamarque, B. Hamelin, T. Vallot, A. Ropert |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Proton-pump inhibitor Gastroenterology Oral administration Internal medicine Gastrins medicine Gastric mucosa Humans Pharmacology (medical) Enzyme Inhibitors Omeprazole Gastrin Gastric Acidity Determination Hepatology biology business.industry Healthy subjects Proton Pump Inhibitors Anti-Ulcer Agents biology.organism_classification Endocrinology medicine.anatomical_structure Gastric Mucosa Tasa Female business medicine.drug |
| Zdroj: | Alimentary Pharmacology and Therapeutics. 11:747-753 |
| ISSN: | 1365-2036 0269-2813 |
| Popis: | Background: Prolonged treatment with omeprazole 20 or 40 mg/day is sometimes required, especially for severe oesophagitis. However, information about long-term effects on intragastric acidity and plasma gastrin response with such drug regimens is scarce. Methods: Sixteen healthy subjects (11 men, 5 women, mean age 29 years) randomly received either 20 or 40 mg of omeprazole once daily (at 08.00 h) for 3 months. Gastric pH was recorded every 6 s for 24 h from noon to noon under standardized conditions, and blood samples were collected hourly in order to determine the 24-h plasma gastrin response on day 0 (pre-entry), day 7, day 28 and day 90. Results: From day 0 to day 7, 24-h median pH increased from 1.7 to 4.6 and mean percentage of time at pH |
| Databáze: | OpenAIRE |
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