Is there an interaction between polycystic ovary syndrome and gingival inflammation?
| Autor: | Nurcan Buduneli, Aliye Akcalı, David F. Lappin, Özgün Özçaka, Nurgün Biçakçi, Banu Öztürk Ceyhan |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
medicine.medical_specialty Saliva medicine.medical_treatment Statistics Nonparametric Gingivitis Young Adult Internal medicine Medicine Humans Receptors Tumor Necrosis Factor Type II Interleukin 6 biology business.industry Interleukin-6 Tumor Necrosis Factor-alpha Insulin Periodontium Gingival Crevicular Fluid Polycystic ovary Endocrinology Receptors Tumor Necrosis Factor Type I Case-Control Studies biology.protein Periodontics Female medicine.symptom business Hyperandrogenism Body mass index Hormone Polycystic Ovary Syndrome |
| Zdroj: | Journal of periodontology. 83(12) |
| ISSN: | 1943-3670 |
| Popis: | The aim of this study is to evaluate the gingival crevicular fluid (GCF), saliva, and serum concentrations of tumor necrosis factor-α (TNF-α), TNF-α receptor-1 (TNF-αR1), TNF-αR2, and interleukin-6 (IL-6) in non-obese females with polycystic ovary syndrome (PCOS) and either clinically healthy periodontium or gingivitis.Thirty-one females with PCOS and healthy periodontium, 30 females with PCOS and gingivitis, and 12 systemically and periodontally healthy females were included in the study. GCF, saliva, and serum samples were collected, and clinical periodontal measurements, body mass index, and Ferriman-Gallwey score (FGS) were recorded. Sex hormones, cortisol, and insulin levels were measured. TNF-α, TNF-αR1, TNF-αR2, and IL-6 were determined by enzyme-linked immunosorbent assay. Kruskal-Wallis followed by Bonferroni-corrected post hoc Mann-Whitney U tests were used to analyze the data.The PCOS + gingivitis group revealed significantly higher GCF, saliva, and serum IL-6 concentrations than the PCOS + healthy group (P0.0001). The two PCOS groups exhibited significantly higher saliva TNF-α concentrations than the control group (P = 0.024 and P = 0.013, respectively). The FGS index was significantly higher in the PCOS + gingivitis group than the PCOS + healthy group (P = 0.030). The PCOS + gingivitis group revealed significantly higher insulin concentration than the PCOS + healthy and control groups (P = 0.014 and P0.0001, respectively). Serum TNF-α, TNF-αRs, and serum, GCF, and salivary IL-6 levels correlated with the clinical periodontal measurements.PCOS and gingival inflammation appear to act synergistically on the proinflammatory cytokines IL-6 and TNF-α. Thus, PCOS may have an impact on gingival inflammation or vice versa. Additional studies are warranted to clarify the possible relationship between PCOS and periodontal disease. |
| Databáze: | OpenAIRE |
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