Gustatory and metabolic perception of nutrient stress in Drosophila
| Autor: | Brian Y. Chung, Nancy J. Linford, Jennifer Ro, Scott D. Pletcher |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Taste
media_common.quotation_subject Sensory system Synaptic Transmission Stress Physiological Perception medicine Animals media_common Appetitive Behavior Multidisciplinary Dopaminergic Neurons Dopaminergic Nutrient stress Taste Perception Adaptive response Biological Sciences Sleep in non-human animals Survival Analysis Sleep deprivation Drosophila melanogaster Food Sleep Deprivation medicine.symptom Psychology Sleep Neuroscience |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 112(8) |
| ISSN: | 1091-6490 |
| Popis: | Sleep loss is an adaptive response to nutrient deprivation that alters behavior to maximize the chances of feeding before imminent death. Organisms must maintain systems for detecting the quality of the food source to resume healthy levels of sleep when the stress is alleviated. We determined that gustatory perception of sweetness is both necessary and sufficient to suppress starvation-induced sleep loss when animals encounter nutrient-poor food sources. We further find that blocking specific dopaminergic neurons phenocopies the absence of gustatory stimulation, suggesting a specific role for these neurons in transducing taste information to sleep centers in the brain. Finally, we show that gustatory perception is required for survival, specifically in a low nutrient environment. Overall, these results demonstrate an important role for gustatory perception when environmental food availability approaches zero and illustrate the interplay between sensory and metabolic perception of nutrient availability in regulating behavioral state. |
| Databáze: | OpenAIRE |
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