Leveraging Electron‐Deficient Iminium Intermediates in a General Synthesis of Valuable Amines

Autor:	Che‐Sheng Hsu, Carlos R. Gonçalves, Veronica Tona, Amandine Pons, Marcel Kaiser, Nuno Maulide
Rok vydání:	2022
Předmět:	Electrons General Chemistry Alkenes Amines Catalysis Amination
Zdroj:	Angewandte Chemie International Edition. 61
ISSN:	1521-3773 1433-7851
DOI:	10.1002/anie.202115435
Popis:	The development of reactions converting alkenes and alkynes into valuable building blocks remains one of the main goals of synthetic chemistry. Herein, we present the leveraging of highly electron-deficient iminium ions, rare and fleeting intermediates, into a general amine synthesis. This enables the preparation of amines bearing e.g. valuable α-trifluoromethyl moieties under mild conditions. This broad concept is highlighted by the late-stage amination of quinine into a biologically interesting new analogue.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::debeb9c165e8d2e54c76ecd5b760605e https://doi.org/10.1002/anie.202115435 Zobrazit plný text záznamu Plný text