A Novel Labdane-Type Trialdehyde from Myoga (Zingiber miogaRoscoe) That Potently Inhibits Human Platelet Aggregation and Human 5-Lipoxygenase
| Autor: | Yasujiro Morimitsu, Yasushi Uda, Yoshio Ozawa, Masako Abe, Toshihiko Osawa, Yoshimasa Nakamura |
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| Rok vydání: | 2006 |
| Předmět: |
Drug Evaluation
Preclinical Polygodial Human platelet Flowers Sesquiterpene Applied Microbiology and Biotechnology Biochemistry Analytical Chemistry Labdane Structure-Activity Relationship chemistry.chemical_compound Zingiberaceae Humans Platelet Lipoxygenase Inhibitors Molecular Biology Aldehydes Molecular Structure biology Spectrum Analysis Organic Chemistry General Medicine biology.organism_classification chemistry Arachidonate 5-lipoxygenase biology.protein Diterpenes Diterpene Platelet Aggregation Inhibitors Biotechnology |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 70:2494-2500 |
| ISSN: | 1347-6947 0916-8451 |
| DOI: | 10.1271/bbb.60226 |
| Popis: | We screened myoga extracts for inhibitors of human platelet aggregation and human 5-lipoxygenase. We identified a novel labdane type of diterpene, together with three known diterpenes (miogadial and galanals A and B) from the flower buds of myoga. Spectroscopic data indicated the structure of the new compound to be 12(E)-labdene-15,16,(8beta)17-trial (miogatrial). Miogatrial and miogadial were potent inhibitors of human platelet aggregation and human 5-lipoxygenase (5-LOX). The sesquiterpene, polygodial, also exhibited strong inhibitory activity against human platelet aggregation and 5-LOX. On the other hand, galanals A and B did not have inhibitory activity in either experimental system. It thus appears that a 3-formyl-3-butenal structure was essential for the potent inhibition of human platelet aggregation and human 5-LOX. |
| Databáze: | OpenAIRE |
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