Circulating T-Regulatory Cells in Neuroblastoma: A Pilot Prospective Study

Autor:	Surender Sherawat, Sameer Bakhshi, T. V. S. V. G. K. Tilak, Sandeep Agarwala, Ritu Gupta, Sreenivas Vishnubhatla
Rok vydání:	2014
Předmět:	Male medicine.medical_specialty medicine.medical_treatment India Patient characteristics Antineoplastic Agents Pilot Projects chemical and pharmacologic phenomena T-Lymphocytes Regulatory Gastroenterology Treg cell Neuroblastoma Internal medicine medicine Humans Prospective Studies IL-2 receptor Child Prospective cohort study Chemotherapy business.industry Infant FOXP3 hemic and immune systems Hematology Flow Cytometry medicine.disease Combined Modality Therapy Oncology Child Preschool Pediatrics Perinatology and Child Health Immunology Female business Stem Cell Transplantation
Zdroj:	Pediatric Hematology and Oncology. 31:717-722
ISSN:	1521-0669 0888-0018
DOI:	10.3109/08880018.2014.886002
Popis:	The objective of our study was to determine baseline Tregs in neuroblastoma patients and correlate with patient characteristics, their change with therapy and at relapse/progression. Flow-cytometric analysis for Treg cells [CD4+CD25+FoxP3+] was done in 14 de novo neuroblastoma patients at diagnosis, post-neoadjuvant chemotherapy and at relapse/progression, along with six healthy controls. Patients had significantly higher baseline Treg frequency than controls [Mean 9.84 ± 3.84 vs 3.16 ± 1.49, P.001]; higher mean Treg frequency in patients with tumors10 cm (P = .004) and there was significant reduction in Treg frequency with neoadjuvant chemotherapy when compared with the baseline value [Mean 3.07 ± 1.24 vs 9.72 ± 3.84, P = .007].
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::debc8aa66f8906dcc330b69aedfa7e23 https://doi.org/10.3109/08880018.2014.886002 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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