An Easy Entry into 2-Halo-3-aryl-4(3H)-quinazoliniminium Halides from Heteroenyne-allenes
| Autor: | Sundeep Rayat, Kusum L. Chandra, John M. Desper, Vijaya Kumar Naganaboina |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Molecular Structure
Hydrogen Hydrocarbons Halogenated Aryl Organic Chemistry Intramolecular cyclization Halide chemistry.chemical_element Ring (chemistry) Biochemistry Combinatorial chemistry Catalysis Alkadienes chemistry.chemical_compound chemistry Cyclization Quinazolines Organic chemistry Lewis acids and bases Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters. 13:3718-3721 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol201372n |
| Popis: | An efficient three-step synthesis of 2-halo-3-aryl-4(3H)-quinazoliniminium halides from commercially available materials is described. Upon reaction with hydrogen halides, generated in situ from a Lewis acid (MX) and trace water, a variety of easily accessible heteroenyne-allenes underwent facile intramolecular cyclization to afford the title compounds in good yields. The method is highly versatile and provides a general way to construct quinazoliniminium ring systems with a variety of different substitutions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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