The Effect of 0.12% Unoprostone Isopropyl (Rescula) on Intraocular Pressure in Normotensive Dogs
Autor: | Ron Ofri, Phillip H. Kass, Dorit Raz, George N. Lambrou, Christine L. Percicot |
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Rok vydání: | 2000 |
Předmět: |
Applanation tonometry
medicine.medical_specialty Intraocular pressure genetic structures Glaucoma Dinoprost Placebo Random Allocation Tonometry Ocular Unoprostone Isopropyl Dogs Ophthalmology medicine Animals Dog Diseases Intraocular Pressure General Veterinary business.industry Fatty Acids Pupil size medicine.disease eye diseases Canine glaucoma Anesthesia sense organs Ophthalmic Solutions business After treatment |
Zdroj: | Journal of Veterinary Medical Science. 62:1313-1315 |
ISSN: | 1347-7439 0916-7250 |
DOI: | 10.1292/jvms.62.1313 |
Popis: | Rescula (0.12% unoprostone isopropyl) is the first docosanoid compound approved for treatment of glaucoma in humans. It is commercially available in Japan, and is undergoing clinical testing elsewhere. The aim of this study was to evaluate the effect of Rescula on intraocular pressure (IOP) in normotensive dogs. After establishing a baseline diurnal IOP curve, six dogs were unilaterally treated with Rescula while the contralateral eye was treated with a placebo. Applanation tonometry was performed in both eyes, and pupil size was evaluated, 30 min after treatment, and at 1-hr intervals for the next 9 hr. Rescula caused a significant (p=0.014) and long-lasting decrease in IOP, from 20.49+/-2.02 mm Hg in control eyes to 15.49+/-0.69 mm Hg in treated eyes. These results suggest that Rescula is potentially efficacious in treatment of canine glaucoma. |
Databáze: | OpenAIRE |
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