Emerging human alveolar echinococcosis in Hungary (2003–2018): a retrospective case series analysis from a multi-centre study
| Autor: | Mária Fehérvári, Thomas F. E. Barth, Attila Patonai, Zsolt Káposztás, Tamás Strausz, Eszter Csulak, Áron Somorácz, Balázs Dezsényi, Z. Tolnai, Veronika Czoma, Tamás Sréter, András Csilek, Attila Oláh, Zsolt Dubóczki, Adriano Casulli, Beate Grüner, József Danka, Herbert Auer, Zoltán Széll, Kálmán Almási, Dénes Görög |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Pediatrics Delayed Diagnosis 030231 tropical medicine Antiprotozoal Agents Albendazole Echinococcus multilocularis lcsh:Infectious and parasitic diseases Diagnosis Differential Young Adult 03 medical and health sciences 0302 clinical medicine Echinococcosis Epidemiology Case fatality rate medicine Animals Humans lcsh:RC109-216 Radical surgery Case series Aged Retrospective Studies Hungary biology business.industry Incidence (epidemiology) Clinical epidemiology Middle Aged 030108 mycology & parasitology biology.organism_classification Infectious Diseases Emerging infectious disease Human alveolar echinococcosis Female Differential diagnosis business Research Article medicine.drug |
| Zdroj: | BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-15 (2021) BMC Infectious Diseases |
| ISSN: | 1471-2334 |
| Popis: | Background Human alveolar echinococcosis (AE) caused by Echinococcus multilocularis is an underreported, often misdiagnosed and mistreated parasitic disease mainly due to its low incidence. The aim of this study was to describe the epidemiological and clinical characteristics of human AE patients in Hungary for the first time. Method Between 2003 and 2018, epidemiological and clinical data of suspected AE patients were collected retrospectively from health database management systems. Results This case series included a total of 16 AE patients. The mean age of patients was 53 years (range: 24–78 years). The sex ratio was 1:1. Four patients (25%) revealed no recurrence after radical surgery and adjuvant albendazole (ABZ) therapy. For five patients (31.3%) with unresectable lesions, a stabilization of lesions with ABZ treatment was achieved. In seven patients (43.8%), progression of AE was documented. The mean diagnostic delay was 33 months (range: 1–122 months). Three AE related deaths (fatality rate 18.8%) were recorded. Conclusions AE is an emerging infectious disease in Hungary with a high fatality rate since based on our results, almost every fifth AE patient died in the study period. Differential diagnosis and appropriate surgical and medical therapy for AE is an urging challenge for clinicians in Hungary, as well as in some other European countries where E. multilocularis is prevalent. |
| Databáze: | OpenAIRE |
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