Comparison of LI-RADS 2018 and KLCA-NCC 2018 for noninvasive diagnosis of hepatocellular carcinoma using magnetic resonance imaging

Autor: Myeong-Jin Kim, Seung-Seob Kim, Hyerim Kim, Sunyoung Lee, Dong ryul Chang
Rok vydání: 2020
Předmět:
Male
medicine.medical_specialty
Carcinoma
Hepatocellular
diagnosis
Contrast Media
Gastroenterology
Sensitivity and Specificity
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Statistical significance
Internal medicine
Carcinoma
medicine
Image Processing
Computer-Assisted
Humans
lcsh:RC799-869
Diagnostic Errors
Molecular Biology
Aged
Retrospective Studies
Hepatology
medicine.diagnostic_test
business.industry
Significant difference
Liver Neoplasms
Cancer
Magnetic resonance imaging
Retrospective cohort study
Middle Aged
Reference Standards
medicine.disease
Magnetic Resonance Imaging
Editorial
Hepatocellular carcinoma
lcsh:Diseases of the digestive system. Gastroenterology
030211 gastroenterology & hepatology
Female
Diagnositic imaging
Liver cancer
business
Zdroj: Clinical and Molecular Hepatology
Clinical and Molecular Hepatology, Vol 26, Iss 3, Pp 340-351 (2020)
ISSN: 2287-285X
Popis: Background/Aims: This study aimed to compare the diagnostic performances of Liver Imaging Reporting and Data System (LI-RADS) 2018 and Korean Liver Cancer Association-National Cancer Center (KLCA-NCC) 2018 criteria on magnetic resonance imaging (MRI) for the noninvasive diagnosis of hepatocellular carcinoma (HCC) in high-risk patients.Methods: This retrospective study included 273 treatment-naïve patients (71 patients with extracellular contrast agent [ECA]-MRI and 202 patients with hepatobiliary agent [HBA]-MRI; 352 lesions including 263 HCCs) with high risk of HCC who underwent contrast-enhanced MRI between 2016 and 2017. Two readers evaluated all lesions according to the criteria of LI-RADS 2018 and KLCA-NCC 2018. The per-lesion diagnostic performances were compared using the generalized estimating equation method.Results: On ECA-MRI, the sensitivity and specificity of LI-RADS 2018 and KLCA-NCC 2018 were not significantly different (LR-5 vs. definite HCC: 75.8% vs. 69.4%, P=0.095 and 95.8% vs. 95.8%, P>0.999; LR-5/4 vs. definite/probable HCC: 87.1% vs.83.9%, P=0.313 and 87.5% vs. 91.7%, P=0.307). On HBA-MRI, definite HCC of KLCA-NCC 2018 showed significantly higher sensitivity (79.1% vs. 68.2%, PP=0.314). Definite/probable HCC of KLCA-NCC 2018 had higher specificity (92.3% vs. 80.0%, P=0.003) than LR-5/4 of LI-RADS 2018. The sensitivity was lower for definite/probable HCC than for LR-5/4 without statistical significance (85.6% vs. 88.1%, P=0.057).Conclusions: On ECA-MRI, LI-RADS 2018 and KLCA-NCC 2018 showed comparable diagnostic performances. On HBA-MRI, definite HCC of KLCA-NCC 2018 provided better sensitivity than LR-5 category of LI-RADS 2018 without compromising the specificity, while definite/probable HCC of KLCA-NCC 2018 revealed higher specificity than LR-5/4 of LI-RADS 2018 for diagnosing HCC.
Databáze: OpenAIRE
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